Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.

Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Research Abstract Details 

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Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Abstract Text:

Floyd L Wormley,John R Perfect,Chad Steele,Gary M Cox,

We evaluated cell-mediated immune (CMI) responses in mice given a pulmonary infection with a Cryptococcus neoformans strain engineered to produce the Th1-type cytokine gamma interferon (IFN-gamma). Mice given a pulmonary infection with an IFN-gamma-producing C. neoformans strain were able to resolve the primary infection and demonstrated complete (100%) protection against a second pulmonary challenge with a pathogenic C. neoformans strain. Pulmonary cytokine analyses showed that Th1-type/proinflammatory cytokine and chemokine expression were significantly higher and Th2-type cytokine expression was significantly lower in mice infected with the IFN-gamma-producing C. neoformans strain compared to wild-type-infected mice. This increased pulmonary Th1-type cytokine expression was also associated with significantly lower pulmonary fungal burden and significantly higher pulmonary leukocyte and T-lymphocyte recruitment in mice infected with the IFN-gamma-producing C. neoformans strain compared to wild-type-infected mice. Our results demonstrate that pulmonary infection of mice with a C. neoformans strain expressing IFN-gamma results in the stimulation of local Th1-type anti-cryptococcal CMI responses and the development of protective host immunity against future pulmonary cryptococcal infections. The use of fungi engineered to produce host cytokines is a novel method to study immune responses to infection and may be useful in developing vaccine strategies in humans.

Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Publishing Authors By Initials

FL Wormley,JR Perfect,C Steele,GM Cox,

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains: mice, inbred balb c research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains: mice, inbred balb c research

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Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 1453-62

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 8

MONTH: 01

YEAR: 2007

Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred BALB C

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.

AFFILIATION: Department Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-0062, USA. floyd.wormley@utsa.edu

Country: United States

AGENCY: United States NIAID

GRANT: P30 AI64518

ACRONYM: AI

MEDLINETA: Infect Immun

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