Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model.

Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model. Research Abstract Details 

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Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model. Abstract Text:

P Giordano,G Lorito,A Ciorba,A Martini,S Hatzopoulos,

Cisplatin (CDDP) is an anti-neoplastic drug extensively used in cases of head and neck cancer. Cisplatin induces numerous untoward side-effects including ototoxicity. In this study, cisplatin ototoxicity in Sprague-Dawley rat animal model has been evaluated and the oto-protection provided by the systemic administration of the antioxidant drug D-methionine has been tested. A total of 12 Sprague-Dawley rats were used: 8 were treated intra-peritoneally with D-methionine (300 mg/kg) and cisplatin (16 mg/kg, slow 30 min-infusion), 4 only with cisplatin. The hearing threshold of the animals was evaluated by electrophysiological procedures as Otoacoustic Emissions and Auditory Brainstem Responses. The effects of protection were evaluated after 72 hours. The data from the Otoacoustic Emissions (in the 4.0-12 kHz band) and Auditory Brainstem Responses recordings suggested that D-methionine can partially protect from Cisplatin ototoxicity.

Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model. Publishing Authors By Initials

P Giordano,G Lorito,A Ciorba,A Martini,S Hatzopoulos,

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Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta otorhinolaryngologica Italica : organo uffici

VOLUME: 26

Page Numbers: 198-207

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ISSN: 0392-100X

DAY: 1

MONTH: Aug

YEAR: 2006

Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model. Information

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LANGUAGE: eng

NlmUniqueID: 8213019

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Grant and Affiliation Information for Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model.

AFFILIATION: Department of Audiology, University of Ferrara, Ferrara, Italy.

Country: Italy

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MEDLINETA: Acta Otorhinolaryngol Ital

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