Protease research in the era of systems biology.

Protease research in the era of systems biology. Research Abstract Details 

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Protease research in the era of systems biology. Abstract Text:

Ulrich auf dem Keller,Alain Doucet,Christopher M Overall,Ulrich auf dem Keller,Alain Doucet,Christopher M Overall,

Proteases are specific modulators of signaling molecules and their underlying pathways in addition to their degradative roles. However, proteases do not act alone, but form cascades, circuits and networks that all dynamically interconnect to form the protease web, which defines the proteolytic potential of a cell or tissue in a defined condition. To describe the protease web and its net activity several novel high-throughput proteomic techniques, in the field termed degradomics, have been developed. Emerging systems biology methods to evaluate the expression, activity and substrate discovery of proteases are presented. Understanding the protease web and its perturbations in pathology will help to develop new therapeutics for the treatment of diseases, such as cancer, arthritis and chronic obstructive pulmonary diseases.

Protease research in the era of systems biology. Publishing Authors By Initials

U auf dem Keller,A Doucet,CM Overall,U auf dem Keller,A Doucet,CM Overall,

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Protease research in the era of systems biology. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological chemistry

VOLUME: 388

Page Numbers: 1159-62

Journal Abbreviation: Biol. Chem.

ISSN: 1431-6730

DAY: 2

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9700112

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Grant and Affiliation Information for Protease research in the era of systems biology.

AFFILIATION: The UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

Country: Germany

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MEDLINETA: Biol Chem

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