Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer.

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Abstract Text:

David P Turner,Omar Moussa,Moira Sauane,Paul B Fisher,Dennis K Watson,

Cell migration and invasion are critical events during the progression to metastasis. Without motile function, cancer cells are unable to leave the primary tumor site, invade through the basement membrane, and form secondary tumors. Expression of the epithelial-specific ETS factor prostate-derived ETS factor (PDEF) is reduced in human invasive breast tissue and lost in invasive breast cancer cell lines. Gain-of-function studies that examine different aspects of cell migration show that constitutive or inducible PDEF reexpression inhibits migration and invasion in multiple breast cancer cell lines, and loss-of-function studies show a stimulation of migration in noninvasive breast cancer cells. Furthermore, the introduction of PDEF into invasive breast cancer cells led to a remodeling of the actin cytoskeleton and altered focal adhesion localization and adherence levels. Cells expressing PDEF no longer form the defined morphologic polarity required for efficient, directional migration. Collectively, these data indicate that PDEF down-regulation in invasive breast cancer may promote actin-mediated cell migration through the extracellular matrix.

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Publishing Authors By Initials

DP Turner,O Moussa,M Sauane,PB Fisher,DK Watson,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

PUBMED ID PMID:

MEDLINE DATE:

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 67

Page Numbers: 1618-25

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Feb

YEAR: 2007

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: genetics

Chemical & Substance for Abstract: Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Information

Substance Name: SPDEF protein, human

Registry Number: 0

Grant and Affiliation Information for Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer.

AFFILIATION: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA 35675

ACRONYM: CA

MEDLINETA: Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer Related Publications

• A specific dileucine motif is required for the GGA-dependent entry of newly synthesized insulin-responsive aminopeptidase into the insulin-responsive compartment.
• Advancing quality of urinary incontinence evaluation and treatment in nursing homes through translational research.
• Assessing acrosomal status of bovine sperm using fluoresceinated lectins.
• Characterization of epithelial cell shedding from human small intestine.
• Clinical report: Recovery of a degenerating 14-day embryo in the uterine flush of a mare 7 days after ovulation.
• Current status of newborn screening: decision-making about the conditions to include in screening programs.
• Distraction osteogenesis.
• Do mares possess an intracellular endometrial inhibitor of prostaglandin synthesis during early pregnancy?
• Effect of bone morphogenetic proteins 2 and 7 on septal chondrocytes in alginate.
• Health seeking behavior by families of children suspected to have malaria in Kabale: Uganda.
• Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia.
• Hp19 re-operation for Dysphagia after cardiomyotomy for achalasia.
• Hp23 use of anti-reflux medication after anti-reflux surgery.
• Hp33p laparoscopic anti-reflux surgery in the elderly.
• Human Papillomavirus: Confronting the Epidemic-A Urologist's Perspective.
• Lowering levels of lipids and homocysteine.
• Molecular mechanisms of megakaryopoiesis.
• Paradoxical embolism secondary to ovarian carcinoma resulting in stroke.
• Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer.
• Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development.
• Screening for colorectal cancer using the faecal occult blood test, Hemoccult.
• Single- versus dual-process models of lexical decision performance: insights from response time distributional analysis.
• Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy.
• Stroke prevention in atrial fibrillation: antiplatelet therapy revisited.
• The effect of buffer osmolality on the survival of cat (Felis catus ) spermatozoa at 5 degrees C.
• The effect of high and low dose Theileria parva infection on the reproductive function of Boran/Friesian heifers.
• The effect of transcervical uterine manipulations on establishment of uterine infection in mares under the influence of progesterone.
• The effects of low level of feeding on response to synchronization of estrus, ovulation rate and embryo loss in goats.
• Understanding the impact of stigma on people with mental illness.
• von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively.