Prostaglandins: modulators of inflammation and cardiovascular risk.

Prostaglandins: modulators of inflammation and cardiovascular risk. Research Abstract Details 

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Prostaglandins: modulators of inflammation and cardiovascular risk. Abstract Text:

Garret A Fitzgerald,

Cyclooxygenase (COX)-2-specific drugs such as rofecoxib and celecoxib and the newer agents, etoricoxib and valdecoxib, were developed to provide a safer alternative to traditional nonsteroidal antiinflammatory drugs (tNSAIDs). These drugs have been shown significantly to reduce endoscopically visualized gastrointestinal ulcers, and one of them, rofecoxib, has demonstrated a 50% reduction in clinically important gastrointestinal outcomes compared with a tNSAID. However, COX-derived prostaglandins also have complex interactions with the cardiovascular system. This article briefly reviews our current understanding of the interactions between prostaglandins and cardiovascular physiology, and addresses some of the concerns that recently have been raised regarding coxibs and the risk of cardiovascular events.

Prostaglandins: modulators of inflammation and cardiovascular risk. Publishing Authors By Initials

GA Fitzgerald,

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Prostaglandins: modulators of inflammation and cardiovascular risk. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical rheumatology : practical repor

VOLUME: 10

Page Numbers: S12-7

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ISSN: 1076-1608

DAY: 17

MONTH: Jun

YEAR: 2004

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LANGUAGE: eng

NlmUniqueID: 9518034

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AFFILIATION: From the University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania.

Country: United States

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MEDLINETA: J Clin Rheumatol

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