Prostaglandin E(2) receptors in bone formation.

Prostaglandin E(2) receptors in bone formation. Research Abstract Details 

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Prostaglandin E(2) receptors in bone formation. Abstract Text:

M Li,D D Thompson,V M Paralkar,M Li,D D Thompson,V M Paralkar,

Prostaglandins, PGE(2) in particular, have diverse actions on various organs, including inflammation, bone healing, bone formation, embryo implantation, induction of labour and vasodilatation, among others. However, systemic side effects have limited their clinical utility. The pharmacological activities of PGE(2) are mediated through four G protein-coupled receptor subtypes, EP1-EP4. Recent studies have shown that EP2 and EP4 receptors play important roles in regulating bone formation and resorption. EP2 and EP4 receptor-selective agonists have been shown to stimulate local or systemic bone formation, augment bone mass and accelerate the healing of fractures or bone defects in animal models upon local or systemic administration, thus, potentially offering new therapeutic options for enhancing bone formation and bone repair in humans. This review will focus on the studies related to bone formation and bone healing in the EP receptor knockout (KO) mice and the EP2 or EP4 receptor-selective agonist treated animal models.

Prostaglandin E(2) receptors in bone formation. Publishing Authors By Initials

M Li,DD Thompson,VM Paralkar,M Li,DD Thompson,VM Paralkar,

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Prostaglandin E(2) receptors in bone formation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International orthopaedics

VOLUME: 31

Page Numbers: 767-72

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ISSN: 0341-2695

DAY: 26

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7705431

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Grant and Affiliation Information for Prostaglandin E(2) receptors in bone formation.

AFFILIATION: Pfizer Global Research and Development, Groton Laboratories, Mail Stop 8118W-208, Groton, CT, 06340, USA, mei.li@pfizer.com.

Country: Germany

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MEDLINETA: Int Orthop

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