Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits.

Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits. Research Abstract Details 

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Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits. Abstract Text:

Yuka Fukuda,Motoi Sugimura,Kazunao Suzuki,Naohiro Kanayama,Yuka Fukuda,Motoi Sugimura,Kazunao Suzuki,Naohiro Kanayama,

BACKGROUND: The purpose of this study was to examine whether EP4 as prostaglandin (PG) E2 receptor is involved in lipopolysaccharide (LPS)-induced cervical ripening. METHODS: New Zealand White non-pregnant rabbits were randomly allocated to 4 equal groups and treated with vaginal suppositories containing LPS with various concentrations of EP4-selective antagonist once daily for 3 days, and then sacrificed for analysis. Analysis was performed in order to examine the inhibitory effect of EP4 antagonist on LPS-induced cervical ripening. The expression of EP4 in a cervix treated with LPS was examined immunohistochemically. The percent of cervical extensibility in the segment of cervix as the tensile strength was determined with 5.8 g of constant perpendicular stretching. The ripening area of the cervix with edematous changes in H&E sections was calculated by a microscopic system with a computer-assisted digital analyser. Type-1 collagenase activity was determined in cervical tissue using FITC-labelled type-1 collagen. RESULTS: Immunohistochemical study shows the positive staining of EP4 at the interstitial cells in the cervix treated with LPS. The extensibility, cervical edematous area and type-1 collagenase activity are significantly reduced in the cervix treated with LPS in the presence of EP4 antagonist compared with that treated with LPS alone. CONCLUSIONS: These data implicates the EP4 as the PGE2 receptor involved in LPS-induced cervical ripening.

Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits. Publishing Authors By Initials

Y Fukuda,M Sugimura,K Suzuki,N Kanayama,Y Fukuda,M Sugimura,K Suzuki,N Kanayama,

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Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta obstetricia et gynecologica Scandinavica

VOLUME: 86

Page Numbers: 1297-302

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ISSN: 1600-0412

DAY: 26

MONTH: 10

YEAR: 2007

Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 370343

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Grant and Affiliation Information for Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits.

AFFILIATION: Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Country: Denmark

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MEDLINETA: Acta Obstet Gynecol Scand

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