Prospective teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and loss of CYP26 activity.

Prospective teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and loss of CYP26 activity. Research Abstract Details 

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Prospective teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and loss of CYP26 activity. Abstract Text:

P McCaffery,C Simons,P McCaffery,C Simons,

All-trans retinoic acid (atRA) is the transcriptionally active product of vitamin A and induces gene expression via specific receptors at nM concentrations. Essential enzymes that regulate the local levels of atRA are the CYP26 members of the cytochrome P450 family, which catabolize atRA. Compounds that have been designed to inhibit these enzymes are known as Retinoic Acid Metabolic Blocking Agents (RAMBAs). Treatment with these compounds will raise endogenous atRA levels and may be therapeutic for the treatment of diseases that respond to high atRA concentrations, including several types of cancer as well as skin conditions such as psoriasis and acne. This review describes the mechanism of action of the RAMBAs and discusses the potential side effects of these compounds. atRA is highly teratogenic and the potential teratogenicity of the RAMBAs is described by comparison with the abnormalities resulting from null mutation of individual CYP26 genes. The possible effects of RAMBAs on the adult brain are also described that have the potential for harm but, in the right circumstances, may also be beneficial.

Prospective teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and loss of CYP26 activity. Publishing Authors By Initials

P McCaffery,C Simons,P McCaffery,C Simons,

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Prospective teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and loss of CYP26 activity. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical design

VOLUME: 13

Page Numbers: 3020-37

Journal Abbreviation: Curr. Pharm. Des.

ISSN: 1873-4286

DAY: 5

MONTH: 11

YEAR: 2007

Prospective teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and loss of CYP26 activity. Information

Number of References: 156

LANGUAGE: eng

NlmUniqueID: 9602487

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AFFILIATION: Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. p.j.mccaffery@abdn.ac.uk

Country: Netherlands

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