Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study.

Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Research Abstract Details 

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Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Abstract Text:

Laura D Kubzansky,Karestan C Koenen,Avron Spiro,Pantel S Vokonas,David Sparrow,

CONTEXT: Various correlates of posttraumatic stress disorder (PTSD), such as high levels of sympathetic activation and hypothalamic-pituitary-adrenal axis dysregulation, have been linked to arterial damage and coronary heart disease (CHD) risk. While psychological disturbance is frequently found among patients with cardiac disease, whether psychological problems precede or occur as a result of having a potentially fatal disease is not clear. To our knowledge, no prospective studies to date have evaluated whether PTSD is associated with increased risk of CHD. OBJECTIVE: To test the hypothesis that high levels of PTSD symptoms may increase CHD risk, using 2 different measures of PTSD. DESIGN: Prospective cohort study. SETTING: Community-dwelling men from the Greater Boston, Mass, area who served in the military. PARTICIPANTS: Data are from the Veterans Affairs Normative Aging Study. Men who completed either the Mississippi Scale for Combat-Related PTSD in 1990 (n = 1002) or the Keane PTSD scale in 1986 (n = 944) were included in the study. MAIN OUTCOME MEASURE: Incident CHD occurring during follow-up through May 2001. RESULTS: Levels of PTSD symptoms in this cohort were low to moderate. Men with preexisting CHD at baseline were excluded, and PTSD was measured with the Mississippi Scale for Combat-Related PTSD. For each SD increase in symptom level, men had age-adjusted relative risks of 1.26 (95% confidence interval, 1.05-1.51) for nonfatal myocardial infarction and fatal CHD combined and 1.21 (95% confidence interval, 1.05-1.41) for all of the CHD outcomes combined (nonfatal myocardial infarction, fatal CHD, and angina). Findings were replicated using the Keane PTSD scale and somewhat strengthened after controlling for levels of depressive symptoms. CONCLUSIONS: To our knowledge, this is the first study to demonstrate a prospective association between PTSD symptoms and CHD even after controlling for depressive symptoms. These results suggest that a higher level of PTSD symptoms may increase the risk of incident CHD in older men.

Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Publishing Authors By Initials

LD Kubzansky,KC Koenen,A Spiro,PS Vokonas,D Sparrow,

For similar mental disorders: anxiety disorders: stress disorders, traumatic: stress disorders, post-traumatic research abstracts see: mental disorders: anxiety disorders: stress disorders, traumatic: stress disorders, post-traumatic research

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Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of general psychiatry

VOLUME: 64

Page Numbers: 109-16

Journal Abbreviation: Arch. Gen. Psychiatry

ISSN: 0003-990X

DAY: 3

MONTH: Jan

YEAR: 2007

Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Information

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LANGUAGE: eng

NlmUniqueID: 372435

Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study. Keywords Mesh Terms:

KEYWORDS: Stress Disorders, Post-Traumatic

MESH TERMS: epidemiology

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Grant and Affiliation Information for Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study.

AFFILIATION: Harvard School of Public Health, Veterans Affairs Normative Aging Study, Veterans Affairs Boston Health Care System, Boston University School of Medicine, 677 Huntington Avenue, Boston, MA 02115, USA. lkubzans@hsph.harvard.edu

Country: United States

AGENCY: United States NIA

GRANT: R29 AG 07465

ACRONYM: AG

MEDLINETA: Arch Gen Psychiatry

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