Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction.

Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Research Abstract Details 

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Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Abstract Text:

The objective of this study was to evaluate ten methods for calculating creatinine clearance (Clcr) in children with renal dysfunction. The design was a prospective, comparative study using 24-h urinary Clcr as the criterion standard. Twenty-two children (age 7-16 years old) were studied. Urinary Clcr ranged from 0 to 161 ml/min/1.73 m2. Calculated Clcr and 24-h urinary Clcr were evaluated statistically. Linear regression analysis, nominal frequency, and mean relative error were used to rank the methods. Children were stratified based on gender and renal function. None of the methods correlated well when Clcr > 100 ml/min/1.73 m2. Predictive performance deteriorated as Clcr decreased. Simple methods using height and serum creatinine were best. Clcr (ml/min/1.73 m2) = (0.52 x height (cm)/serum creatinine)--3.6 was the best equation for estimating Clcr in our patient population consisting of children over 7 years of age with stable serum creatinine.

Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Publishing Authors By Initials

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 20

Page Numbers: 67-73

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Apr

YEAR: 1995

Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction.

AFFILIATION: College of Pharmacy, University of Colorado, Denver, USA.

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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