Proresorptive Actions of FSH and Bone Loss.

Proresorptive Actions of FSH and Bone Loss. Research Abstract Details

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Proresorptive Actions of FSH and Bone Loss. Abstract Text:

Mone Zaidi,Harry C Blair,Jameel Iqbal,Ling Ling Zhu,T Rajendra Kumar,Alberta Zallone,Li Sun,Mone Zaidi,Harry C Blair,Jameel Iqbal,Ling Ling Zhu,T Rajendra Kumar,Alberta Zallone,Li Sun,Mone Zaidi,Harry C Blair,Jameel Iqbal,Ling Ling Zhu,T Rajendra Kumar,Alberta Zallone,Li Sun,

We review studies that propose follicle-stimulating hormone (FSH) as a physiologic stimulator of osteoclastic bone resorption. We hypothesize that, in addition to low estrogen, a rising FSH contributes to the increased bone resorption and bone loss in hypergonadism. This is of particular relevance to the perimenopausal transition, wherein profound bone loss is accompanied by trabecular perforations in the face of high FSH and normal estrogen levels. Potential therapeutic implications include the development of antagonists to both circulating FSH and its osteoclastic receptor.

Proresorptive Actions of FSH and Bone Loss. Publishing Authors By Initials

M Zaidi,HC Blair,J Iqbal,LL Zhu,TR Kumar,A Zallone,L Sun,M Zaidi,HC Blair,J Iqbal,LL Zhu,TR Kumar,A Zallone,L Sun,M Zaidi,HC Blair,J Iqbal,LL Zhu,TR Kumar,A Zallone,L Sun,

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Proresorptive Actions of FSH and Bone Loss. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1116

Page Numbers: 376-82

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 17

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7506858

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AFFILIATION: The Mount Sinai School of Medicine, Division of Endocrinology, Box 1055, One Gustave L. Levy Place, Atran Building AB4-02, New York, NY 10029. Li.sun@mssm.edu.

Country: United States