Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization.

Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Research Abstract Details 

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Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Abstract Text:

A Akin,A Esmaoglu,G Guler,R Demircioglu,N Narin,A Boyaci,

We investigated the effects of propofol and propofol-ketamine on hemodynamics, sedation level, and recovery period in pediatric patients undergoing cardiac catheterization. We performed a prospective, randomized, double-blind study. The study included 60 American Society of Anesthesiologists physical status II or III (age range, 1 month-13 years) undergoing cardiac catheterization for evaluation of congenital heart disease. Propofol and ketamine were prepared in 5% glucose solution to a final concentration of 5 and 1 mg/ml, respectively; similar injectors containing 5% glucose solution only were prepared. Fentanyl (1 microg/kg) and propofol (1.5 mg/kg) were given to both groups. Then, group 1 received 0.5 ml/kg of 5% glucose and group 2 0.5 ml/kg of ketamine solution by an anesthesiologist who was unaware of the groups of patients. Local anesthesia with 1% lidocaine was administered before intervention in all patients. The noninvasively measured mean arterial pressure, heart rate, respiratory rate, and peripheral oxygen saturation were recorded at the baseline, following drug administration, at 3, 5, 10, 15, 20, and 30 minutes and then at 15-minute intervals until the end of the procedure. Additional drug and fentanyl requirements to maintain a sedation level of 4 or 5 were recorded. After the procedure, the time to a Steward recovery score of 6 and adverse effects in the first 24 hours were recorded. The number of patients with more than a 20% decrease in mean arterial pressure was 11 in group 1 and 3 in group 2 (p < 0.05). The number of patients who experienced more than a 20% decrease in heart rate was 12 in group 1 and 5 in group 2 (p = 0.054). Ten patients in group 1 and 3 patients in group 2 required additional fentanyl doses (p = 0.057). The number of additional propofol doses was lower in group 2 (p < 0.05). Propofol combined with low-dose ketamine preserves mean arterial pressure better without affecting the recovery and thus is a good option in pediatric patients undergoing cardiac catheterization.

Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Publishing Authors By Initials

A Akin,A Esmaoglu,G Guler,R Demircioglu,N Narin,A Boyaci,

For similar circulatory and respiratory physiology: respiratory physiology research abstracts see: circulatory and respiratory physiology: respiratory physiology research

PUBMED ID PMID:

MEDLINE DATE: 2005 Sep-Oct

Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Pediatric cardiology

VOLUME: 26

Page Numbers: 553-7

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Keywords Mesh Terms:

KEYWORDS: Respiratory Physiology

MESH TERMS: drug effects

Chemical & Substance for Abstract: Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Information

Substance Name: Ketamine

Registry Number: 6740-88-1

Grant and Affiliation Information for Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization.

AFFILIATION: Department of Anesthesiology, Erciyes, University School of Medicine, Kayseri, Turkey. aaynur@erciyes.edu.tr

Country: United States

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MEDLINETA: Pediatr Cardiol

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