Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells.

Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. Research Abstract Details 

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Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. Abstract Text:

Yeon Suk Jung,Shin-ei Matsumoto,Makiko Yamashita,Kosuke Tomimatsu,Kiichiro Teruya,Yoshinori Katakura,Sanetaka Shirahata,Yeon Suk Jung,Shin-ei Matsumoto,Makiko Yamashita,Kosuke Tomimatsu,Kiichiro Teruya,Yoshinori Katakura,Sanetaka Shirahata,

We have established an in vitro immunization protocol whereby human peripheral blood mononuclear cells (PBMCs) are initially treated with L-leucyl-L-leucine methyl ester (LLME) and subsequently sensitized with antigen in the presence of interleukin (IL)-2, IL-4, and adjuvant. This protocol resulted in the production of antigen-specific antibodies. PBMCs are potentiated to react with exogenous antigens upon treatment with LLME. We are using this system to investigate the immunomodulatory activity of additives. In the present study, we aimed to evaluate the immunomodulatory activity of Propionibacterium acnes (P. acnes), which is known to exhibit various immunomodulatory effects in murine models, using this in vitro immunization protocol. P. acnes was found to augment the production of antigen-specific antibodies by PBMC, possibly through increased production of inflammatory cytokines and/or increased T-B cell interaction. P. acnes hence appears to act as an adjuvant in the antibody response in in vitro immunization.

Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. Publishing Authors By Initials

YS Jung,SE Matsumoto,M Yamashita,K Tomimatsu,K Teruya,Y Katakura,S Shirahata,YS Jung,SE Matsumoto,M Yamashita,K Tomimatsu,K Teruya,Y Katakura,S Shirahata,

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Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 71

Page Numbers: 1963-9

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 0916-8451

DAY: 7

MONTH: 08

YEAR: 2007

Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. Information

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LANGUAGE: eng

NlmUniqueID: 9205717

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Grant and Affiliation Information for Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells.

AFFILIATION: Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Fukuoka, Japan.

Country: Japan

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MEDLINETA: Biosci Biotechnol Biochem

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