Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study.

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Abstract Text:

Chandra Kant Pandey,S Priye,S P Ambesh,S Singh,U Singh,P K Singh,

BACKGROUND: Gabapentin is an antiepileptic drug. Its antiemetic effect is demonstrated in chemotherapy-induced acute and delayed onset of nausea and vomiting in breast cancer patients. AIM: To evaluate the antiemetic effect of gabapentin on incidence and severity of postoperative nausea and vomiting in laparoscopic cholecystectomy. SETTINGS AND DESIGN: Double-blind, randomized, placebo-controlled study. MATERIALS AND METHODS: Two hundred and fifty patients of ASA physical status I and II, scheduled for laparoscopic cholecystectomy were randomly assigned into two equal groups to receive 600 mg gabapentin or matching placebo two hours before surgery. Standard anaesthesia technique was used. Fentanyl was used as rescue postoperative analgesic. Ondansetron 4 mg was used intravenously as rescue medication for emesis. The total number of patients who had nausea or vomiting, and its severity and total fentanyl consumption in the first 24 hours were recorded. STATISTICAL ANALYSIS: "Z test" was used to test the significance of severity of post-operative nausea and vomiting between groups. Fentanyl consumed in each group (Mean+/-SD) within 24 hrs was compared using student t test. P value Results: There were no demographic difference between the two groups. Incidence of post-operative nausea and vomiting within 24 hrs after laparoscopic cholecystectomy was significantly lower in gabapentin group (46/125) than in the placebo group (75/125) (37.8% vs 60%; P =0.04). There was a significantly decreased fentanyl consumption in gabapentin group (221.2+/-92.4 microg) as compared to placebo group (505.9+/-82.0 microg; P =0.01). CONCLUSION: Gabapentin effectively suppresses nausea and vomiting in laparoscopic cholecystectomy and post-operative rescue analgesic requirement.

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Publishing Authors By Initials

CK Pandey,S Priye,SP Ambesh,S Singh,U Singh,PK Singh,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of postgraduate medicine

VOLUME: 52

Page Numbers: 97-100

Journal Abbreviation:

ISSN: 0022-3859

DAY: 8

MONTH: 05

YEAR: 2006

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985196

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study.

AFFILIATION: Departments of Anaesthesiology and Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014, India. ckpandey@sgpgi.ac.in.

Country: India

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Postgrad Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study Related Publications

• A definition of the breeding season of Pool Dorset ewes.
• A shift from significance test to hypothesis test through power analysis in medical research.
• Bio-histopathological studies of endometrium in repeat breeding buffaloes (Bubalus bubalis).
• Challenging and Changing Gender Attitudes among Young Men in Mumbai, India.
• Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2.
• ERK/MAPK pathway regulates GABAA receptors.
• Effect of adenotonsillitis on peak exploratory flow rate in children.
• Effects of bull and heparin and sperm concentrations on in vitro fertilization of buffalo (Bubalus bubalis ) oocytes matured in vitro.
• Efficacy of the Hamilton Thorn Motility Analyzer (HTM-2030) for the evaluation of bovine semen.
• Embryo transfer as a means of controlling the transmission of viral infections. XIII. Failure to transmit foot-and-mouth disease virus through the transfer of embryos from viremic donors.
• Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway.
• GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions.
• How much canola or cottonseed meals can be used for commercial chicken meat production.
• In patients with mild hypertension, does exercise and a gradual rather than abrupt increase in fatty acid and salt intake cause less rise in cardiovascular risk factors?
• In vitro maturation and fertilization of buffalo oocytes (Bubalus bubalis ): Effects of media, hormones and sera.
• Integrated preconcentration SDS-PAGE of proteins in microchips using photopatterned cross-linked polyacrylamide gels.
• Interaction of maternal protein and carbon monoxide on pup mortality in mice: implications for global infant mortality.
• Mitochondria as targets for detection and treatment of cancer.
• On-chip native gel electrophoresis-based immunoassays for tetanus antibody and toxin.
• Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.
• Plasma alpha-tocopherol profiles in sheep after oral administration of dl-alpha-tocopheryl acetate and d-alpha-tocopheryl succinate.
• Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study.
• Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin.
• Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer.
• Responses of different doses of prostaglandin F(2) alpha on estrus induction, fertility and progesterone levels in subestrous buffaloes.
• Seasonal variation in freezability of buffalo semen.
• Steroid receptor coactivator AIB1 in endometrial carcinoma, hyperplasia and normal endometrium: Correlation with clinicopathologic parameters and biomarkers.
• The mental health challenge in Sri Lanka from working within the disaster area.
• Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.
• Variation in angiotensin-converting enzyme activity in the testes of prepubertal, pubertal and adult cockerels.