Property-based sequence representations do not adequately encode local protein folding information.

Property-based sequence representations do not adequately encode local protein folding information. Research Abstract Details 

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Property-based sequence representations do not adequately encode local protein folding information. Abstract Text:

A D Solis,S Rackovsky,

We examine the informatic characteristics of amino acid representations based on physical properties. We demonstrate that sequences rewritten using contracted alphabets based on physical properties do not encode local folding information well. The best four-character alphabet can only encode approximately 57% of the maximum possible amount of structural information. This result suggests that property-based representations that operate on a local length scale are not likely to be useful in homology searches and fold-recognition exercises.

Property-based sequence representations do not adequately encode local protein folding information. Publishing Authors By Initials

AD Solis,S Rackovsky,

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Property-based sequence representations do not adequately encode local protein folding information. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proteins

VOLUME: 67

Page Numbers: 785-8

Journal Abbreviation: Proteins

ISSN: 1097-0134

DAY: 1

MONTH: Jun

YEAR: 2007

Property-based sequence representations do not adequately encode local protein folding information. Information

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LANGUAGE: eng

NlmUniqueID: 8700181

Property-based sequence representations do not adequately encode local protein folding information. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Property-based sequence representations do not adequately encode local protein folding information. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Property-based sequence representations do not adequately encode local protein folding information.

AFFILIATION: Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA.

Country: United States

AGENCY: United States NLM

GRANT: 2R01 LM-06789

ACRONYM: LM

MEDLINETA: Proteins

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