Properties of liposomal membranes containing lysolecithin.

Properties of liposomal membranes containing lysolecithin. Research Abstract Details 

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Properties of liposomal membranes containing lysolecithin. Abstract Text:

T Kitagawa,K Inoue,S Nojima,

Liposomes have been prepared with lysolecithin (1-acyl-sn-3-glycerylphosphorylcholine), egg lecithin (3-sn-phosphatidylcholine), dicetyl phosphate, and cholesterol. The ability to function as a barrier to the diffusion of glucose marker and the sensitivities of the liposomes to hypotonic treatment and other reagents which modified the permeability were examined. Generally, lysolecithin incorporation decreased the effectiveness of the membranes as a barrier to glucose and made the membranes more "osmotically fragile." Cholesterol incorporation counteracted the effect of incorporated lysolecithin. The more cholesterol incorporated into liposomes, the more lysolecthin could be incorporated into the membrane without loss of function as a barrier. With more than 50 mole% of colesterol, lysolecithin alone could form membranes which were practically impermeable to glucose. The hemolytic activity of lysolecithin was affected by mixing with various lecithins or cholesterol. Liposomes containing lysolecithin, which have the ability to trap glucose marker, showed poor hemolytic activity, while lipid micelles with lysolecithin (which could trap little glucose) showed almost the same hemolytic activity as lysolecithin itself. There seems to be a close correlation between hemolytic activity and barrier function of lipid micelles.

Properties of liposomal membranes containing lysolecithin. Publishing Authors By Initials

T Kitagawa,K Inoue,S Nojima,

For similar organic chemicals: alcohols: glycols: ethylene glycols: polyethylene glycols research abstracts see: organic chemicals: alcohols: glycols: ethylene glycols: polyethylene glycols research

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Properties of liposomal membranes containing lysolecithin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 79

Page Numbers: 1123-33

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 1976

Properties of liposomal membranes containing lysolecithin. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Properties of liposomal membranes containing lysolecithin. Keywords Mesh Terms:

KEYWORDS: Polyethylene Glycols

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Chemical & Substance for Abstract: Properties of liposomal membranes containing lysolecithin. Information

Substance Name: Polyethylene Glycols

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Country: JAPAN

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MEDLINETA: J Biochem

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