Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging.

Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging. Research Abstract Details 

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Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging. Abstract Text:

M S Hughes,J E McCarthy,J N Marsh,J M Arbeit,R G Neumann,R W Fuhrhop,K D Wallace,D R Znidersic,B N Maurizi,S L Baldwin,G M Lanza,S A Wickline,

Qualitative and quantitative properties of the finite part, H(f), of the Shannon entropy of a continuous waveform f(t) in the continuum limit are derived in order to illuminate its use for waveform characterization. Simple upper and lower bounds on H(f), based on features of f(t), are defined. Quantitative criteria for a priori estimation of the average-case variation of H(f) and log E(f), where E(f) is the signal energy of f(t) are also derived. These provide relative sensitivity estimates that could be used to prospectively choose optimal imaging strategies in real-time ultrasonic imaging machines, where system bandwidth is often pushed to its limits. To demonstrate the utility of these sensitivity relations for this application, a study designed to assess the feasibility of identification of angiogenic neovasculature targeted with perfluorocarbon nanoparticles that specifically bind to alpha(v)beta3-integrin expression in tumors was performed. The outcome of this study agrees with the prospective sensitivity estimates that were used for the two receivers. Moreover, these data demonstrate the ability of entropy-based signal receivers when used in conjunction with targeted nanoparticles to elucidate the presence of alpha(v)beta3 integrins in primordial neovasculature, particularly in acoustically unfavorable environments.

Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging. Publishing Authors By Initials

MS Hughes,JE McCarthy,JN Marsh,JM Arbeit,RG Neumann,RW Fuhrhop,KD Wallace,DR Znidersic,BN Maurizi,SL Baldwin,GM Lanza,SA Wickline,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography research

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Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of the Acoustical Society of America

VOLUME: 121

Page Numbers: 3542-57

Journal Abbreviation: J. Acoust. Soc. Am.

ISSN: 1520-8524

DAY: 3

MONTH: Jun

YEAR: 2007

Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging. Information

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LANGUAGE: eng

NlmUniqueID: 7503051

Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging. Keywords Mesh Terms:

KEYWORDS: Ultrasonography

MESH TERMS: diagnosis

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Grant and Affiliation Information for Properties of an entropy-based signal receiver with an application to ultrasonic molecular imaging.

AFFILIATION: School of Medicine, Washington University, St. Louis, Missouri 63108, USA. msh@cvu.wustl.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL042950

ACRONYM: HL

MEDLINETA: J Acoust Soc Am

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