Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer.

Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Research Abstract Details 

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Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Abstract Text:

Lingeng Lu,Dionyssios Katsaros,Andrew Wiley,I A Rigault de la Longrais,Manuela Puopolo,Peter Schwartz,Herbert Yu,

OBJECTIVES: The IGF-II gene has four promoters (P1-P4); each initiates promoter-specific transcription. Studies have shown that IGF-II promoters normally active during fetal growth, but silent in postnatal life, are reactivated in cancer. In a previous study, we found IGF-II transcription evaluated at a common translated region was associated with ovarian cancer progression. This study was conducted to further determine which IGF-II promoters were responsible for the association. METHODS: Promoter-specific transcription at each IGF-II promoter was analyzed in 201 ovarian tumor samples using quantitative RT-PCR. Cox regression analysis was performed to determine the association of IGF-II promoter-specific expression with patient survival. RESULTS: P3 and P4 transcripts were detected more frequently and at significantly higher levels than the transcripts of P1 and P2. P3 and P4 transcripts were strongly correlated with the common IGF-II translated region and were significantly higher in patients with late stage disease, large residual tumor, suboptimal debulking or serous histology compared to those with early stage, small residual tumor, optimal debulking or non-serous histology. Survival analysis showed that patients with high P3 or P4 expression had a 2-fold increase in risk for death compared to those with low P3 or P4. These associations remained significant after adjustment for patient age at surgery, disease stage, tumor grade and histology. P1 and P2 transcripts, however, were not associated with disease characteristics or survival. CONCLUSIONS: These findings suggest that IGF-II transcription from P3 and P4 promoters is important in ovarian cancer and evaluation of IGF-II promoter-specific transcription may have clinical implications in ovarian cancer prognosis and treatment.

Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Publishing Authors By Initials

L Lu,D Katsaros,A Wiley,IA Rigault de la Longrais,M Puopolo,P Schwartz,H Yu,

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Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gynecologic oncology

VOLUME: 103

Page Numbers: 990-5

Journal Abbreviation: Gynecol. Oncol.

ISSN: 0090-8258

DAY: 21

MONTH: 07

YEAR: 2006

Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 365304

Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Keywords Mesh Terms:

KEYWORDS: Reverse Transcriptase Polymerase Chain R

MESH TERMS: analysis

Chemical & Substance for Abstract: Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Information

Substance Name: Insulin-Like Growth Factor II

Registry Number: 67763-97-7

Grant and Affiliation Information for Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer.

AFFILIATION: Department of Epidemiology, Yale Cancer Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520-8034, USA.

Country: United States

AGENCY: United States NIA

GRANT: R01AG21392

ACRONYM: AG

MEDLINETA: Gynecol Oncol

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