Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia.

Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Research Abstract Details 

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Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Abstract Text:

Qinghua Feng,Stephen E Hawes,Joshua E Stern,Amadou Dem,Papa Salif Sow,Birama Dembele,Papa Toure,Pavel Sova,Peter W Laird,Nancy B Kiviat,

We examined the feasibility of using detection of high-risk human papillomavirus (HPV) DNA in combination with the presence of aberrantly methylated genes (DAPK1, RARB, TWIST1, and CDH13) for urine-based cervical cancer screening. Urine samples from 129 Senegalese women, aged 35 years or older, 110 with (same day) biopsy-proven cervical neoplasia [cervical intraepithelial neoplasia grade 1 (CIN-1): n = 9; CIN-2-3/carcinoma in situ (CIS): n = 29; invasive cervical cancer (ICC): n = 72], and 19 without cervical neoplasia on biopsy were examined. Hypermethylation of at least one of the four genes identified 62% of ICC and 28% of CIN-2-3/CIS and was present in only 4% of CIN-1 or normal urines. High-risk HPV DNA was detected in urine in 70% of those with biopsy-proven ICC, 59% of those with CIN-2-3/CIS on biopsy, 44% of those with CIN-1 on biopsy, and only 11% of women negative for cervical neoplasia on biopsy. Urine-based detection of either high-risk HPV or hypermethylation of any of the four genes identified 84% of ICC, 64% of CIN-2-3/CIS, 44% of CIN-1, but only 19% of women negative for cervical neoplasia. The sensitivity for detection of CIN-2-3/CIS/ICC by high-risk HPV DNA or aberrant DNA methylation of four genes seems to be comparable to that of an exfoliated cervical cytology. This study shows the potential feasibility of using molecular markers detected in urine for cervical cancer screening.

Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Publishing Authors By Initials

Q Feng,SE Hawes,JE Stern,A Dem,PS Sow,B Dembele,P Toure,P Sova,PW Laird,NB Kiviat,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1178-84

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Jun

YEAR: 2007

Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Keywords Mesh Terms:

KEYWORDS: Uterine Cervical Neoplasms

MESH TERMS: urine

Chemical & Substance for Abstract: Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia.

AFFILIATION: Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98109, USA. qf@u.washington.edu

Country: United States

AGENCY: United States NCI

GRANT: CA85050

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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