[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia]

[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia] Research Abstract Details 

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[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia] Abstract Text:

O N Gioseffi,F ,P Pardini,M Kitagawa,

T cryptantigen can be exposed on the red cell membrane as a result of removal of terminal glycosides, either by bacterial enzymes or by incomplete synthesis of the cell membrane due to somatic mutation, usually caused by a neoplasm. T-activated erythrocytes have been observed in different pathologies, but they have not been seen associated with other abnormalities of red blood cell proteins described in myelodysplastic syndromes or acute leukaemias. A patient with initial diagnosis of refractory anaemia that evolved into erythroleukaemia showed prolonged T-activation, a depressed A blood-group antigen and an increase of foetal haemoglobin, simultaneously. The evolutive pattern of T-activation suggests more an abnormal erythropoiesis than an enzymatic effect and a certain relationship with the haemolytic syndrome.

[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia] Publishing Authors By Initials

ON Gioseffi,F ,P Pardini,M Kitagawa,

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[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sangre

VOLUME: 36

Page Numbers: 129-33

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ISSN: 0036-4355

DAY: 5

MONTH: Apr

YEAR: 1991

[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia] Information

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LANGUAGE: spa

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AFFILIATION: Hospital Nacional Profesor Alejandro Posadas, Servicio de Hematología, Buenos Aires, Argentina.

Country: SPAIN

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MEDLINETA: Sangre (Barc)

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