Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth.

Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. Research Abstract Details 

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Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. Abstract Text:

Taisei Kanamoto,Setsuko Sato,Hideki Nakashima,Masakazu Inoue,

Granulicatella elegans is a member of normal human oral flora and is thought to be a potent pathogen in endocarditis, especially so-called "culture-negative" endocarditis. To elucidate the pathogenicity of this microorganism in inflammatory diseases, the effect of the extracellular products of this bacteria on human peripheral blood mononuclear cells (PBMCs) was examined. Culture supernatants produced by oral isolates of G. elegans strongly inhibited the proliferation of PBMC stimulated by the T-cell mitogens phytohemagglutinin-P, phorbol 12-myristate 13-acetate, concanavalin A, and staphylococcal enterotoxin B. Purification of the active extracellular product revealed that a fraction containing proteins of approximately 47 kDa showing arginine deiminase activity contributed to the inhibition of PBMC proliferation.

Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. Publishing Authors By Initials

T Kanamoto,S Sato,H Nakashima,M Inoue,

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Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of infection and chemotherapy : official j

VOLUME: 13

Page Numbers: 353-5

Journal Abbreviation: J. Infect. Chemother.

ISSN: 1341-321X

DAY: 30

MONTH: 10

YEAR: 2007

Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Proliferation of mitogen-stimulated human peripheral blood mononuclear cells is inhibited by extracellular arginine deiminase of Granulicatella elegans isolated from the human mouth.

AFFILIATION: Department of Preventive Dentistry, Kagoshima University Dental School, Kagoshima, Japan. iseita@marianna-u.ac.jp

Country: Japan

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MEDLINETA: J Infect Chemother

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