Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle.

Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Research Abstract Details 

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Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Abstract Text:

R Strange,K C Westerlind,A Ziemiecki,A-C Andres,

AIM: During each oestrous cycle, the mammary gland is subject to changes in ovarian hormone levels. It responds with limited proliferation, differentiation and regression. To understand the processes resulting in these changes, particularly the regulation of cell death, we examined protein levels in mammary epithelium during the oestrous cycle of the Sprague-Dawley rat. METHODS: Studies of serum hormone levels, vaginal smears, uterine weight and morphology, mammary gland morphology, proliferation and apoptotic indices, and protein levels during the stages of the Sprague-Dawley rat oestrous cycle were used to examine the response of mammary epithelium to the oestrous cycle. RESULTS: Proliferation of mammary epithelium was greater in diestrus and proestrus, while apoptosis was increased in metestrus and diestrus. Growth factor-, hormone- and anchorage-mediated cell survival signalling, indicated by activation of Stat5A, FAK and Akt 1 and expression of anti-apoptotic Bcl-2 family members, was greater in proestrus and reduced in metestrus. In contrast, the levels of pro-apoptotic Bcl-2 family members and proteins associated with apoptosis in mammary epithelium (TGFbeta3, pStat3) were increased during metestrus and diestrus. CONCLUSION: Decreases in growth factor, hormone and cell attachment survival signals corresponded with increased apoptosis during the second half of the oestrous cycle. The protein levels detected during oestrus suggest parallels to apoptosis in mammary involution.

Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Publishing Authors By Initials

R Strange,KC Westerlind,A Ziemiecki,AC Andres,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta physiologica (Oxford, England)

VOLUME: 190

Page Numbers: 137-49

Journal Abbreviation:

ISSN: 1748-1708

DAY: 13

MONTH: 04

YEAR: 2007

Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101262545

Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: metabolism

Chemical & Substance for Abstract: Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle.

AFFILIATION: Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, CO 80214, USA. robert.strange@uchsc.edu

Country: England

AGENCY: United States NCI

GRANT: K07 CA79554

ACRONYM: CA

MEDLINETA: Acta Physiol (Oxf)

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