Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia.

Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Research Abstract Details 

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Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Abstract Text:

Jennifer K Ho-Chen,Juan J Bustamante,Michael J Soares,

The prolactin (PRL) family of hormones/cytokines is involved in the maintenance of pregnancy and adaptations to physiological stressors. In this report, we identify and characterize a new member of the rat PRL family, examine the impact of maternal hypoxia on placental PRL family gene expression, and investigate maternal adaptive responses to hypoxia. Perusal of the PRL gene family locus in the rat genome resulted in the identification of a putative new member of the rat PRL family. The new member is closely related to the previously reported PRL-like protein-F (PLP-F) and has been named PLP-Fbeta and the originally characterized PLP-F, now termed PLP-Falpha. The two proteins exhibit structural similarities but possess distinct cell- and temporal-specific expression profiles. In vivo hypoxia stimulates placental PLP-Falpha and PLP-E mRNA expression in the rat and mouse, respectively. Rcho-1 trophoblast cells can differentiate into trophoblast giant cells, express PLP-Falpha, and exhibit enhanced PLP-Falpha mRNA levels when cultured under low oxygen tension (2%). Exposure to hypobaric hypoxia during latter part of pregnancy did not significantly impact the expression of PLP-Fbeta mRNA. Finally, exposure to hypobaric hypoxia during midpregnancy led to increased maternal red blood cells, hemoglobin concentrations, hematocrit, and increased concentrations of maternal splenic mRNAs for key proteins involved in hemoglobin synthesis, erythroid Krüppel-like factor, erythroid 5-aminolevulinate synthase-2, and beta-major globin. In summary, adaptive responses to maternal hypoxia include activation of placental PLP-Falpha/E gene expression, which may then participate in maternal hematological adjustments required for maintaining maternal and fetal oxygen delivery.

Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Publishing Authors By Initials

JK Ho-Chen,JJ Bustamante,MJ Soares,

For similar cells: trophoblasts research abstracts see: cells: trophoblasts research

PUBMED ID PMID:

MEDLINE DATE:

Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrinology

VOLUME: 148

Page Numbers: 559-65

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 9

MONTH: 11

YEAR: 2006

Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Keywords Mesh Terms:

KEYWORDS: Trophoblasts

MESH TERMS: metabolism

Chemical & Substance for Abstract: Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia.

AFFILIATION: Institute of Maternal-Fetal Biology, Division of Cancer and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD48861

ACRONYM: HD

MEDLINETA: Endocrinology

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ACCESSION NUMBER: BI276593

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