Projections of diencephalic dopamine neurons into the spinal cord in mice.

Projections of diencephalic dopamine neurons into the spinal cord in mice. Research Abstract Details 

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Projections of diencephalic dopamine neurons into the spinal cord in mice. Abstract Text:

S Qu,W G Ondo,X Zhang,W J Xie,T H Pan,W D Le,

The aim of this study is to investigate the pathway of diencephalic dopaminergic (DA) neuronal innervating into the spinal cord in mice, the pathway is postulated relevant to clinical restless legs syndrome (RLS). Tyrosine hydroxylase (TH) immunohistochemistry was used to identify the DA neuron. The fluorescent tracer Fluoro-Gold (FG) was stereotaxically injected into the T10-L5 spinal cord of CBL57 mice (n=20) seven days before the animals were sacrificed. The diencephalic sections were stained with TH antibody and the FG tracer present in the diencephalic DA neurons were examined under fluoresce microscope. The average number of total DA neurons per side in A11, A12, A13 and A14 was 66+/-8, 221+/-12, 350+/-17 and 254+/-21 respectively. After being injected into the spinal cord, FG reached the DA neurons within the A10 and A11 groups, but didn't target to any other DA neuron groups including the A8 and A9 groups in substantia nigra (SN). The diencephalic A11 DA neurons possessed long axons extending over several segments and possibly traversing the entire length of the spinal cord. It is the first time to report A10 and A11 DA neuron projections into the spinal cord in mice.

Projections of diencephalic dopamine neurons into the spinal cord in mice. Publishing Authors By Initials

S Qu,WG Ondo,X Zhang,WJ Xie,TH Pan,WD Le,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

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Projections of diencephalic dopamine neurons into the spinal cord in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 168

Page Numbers: 152-6

Journal Abbreviation:

ISSN: 0014-4819

DAY: 26

MONTH: 07

YEAR: 2005

Projections of diencephalic dopamine neurons into the spinal cord in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Projections of diencephalic dopamine neurons into the spinal cord in mice. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Projections of diencephalic dopamine neurons into the spinal cord in mice. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Projections of diencephalic dopamine neurons into the spinal cord in mice.

AFFILIATION: Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, NB205, Houston, TX 77030, USA.

Country: Germany

AGENCY: United States DS

GRANT: NINDS 40370

ACRONYM: DS

MEDLINETA: Exp Brain Res

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