Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence.

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. Research Abstract Details 

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Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. Abstract Text:

Michael Schleicher,Benjamin R Shepherd,Yajaira Suarez,Carlos Fernandez-Hernando,Jun Yu,Yong Pan,Lisette M Acevedo,Gerald S Shadel,William C Sessa,Michael Schleicher,Benjamin R Shepherd,Yajaira Suarez,Carlos Fernandez-Hernando,Jun Yu,Yong Pan,Lisette M Acevedo,Gerald S Shadel,William C Sessa,

Prohibitin 1 (PHB1) is a highly conserved protein that is mainly localized to the inner mitochondrial membrane and has been implicated in regulating mitochondrial function in yeast. Because mitochondria are emerging as an important regulator of vascular homeostasis, we examined PHB1 function in endothelial cells. PHB1 is highly expressed in the vascular system and knockdown of PHB1 in endothelial cells increases mitochondrial production of reactive oxygen species via inhibition of complex I, which results in cellular senescence. As a direct consequence, both Akt and Rac1 are hyperactivated, leading to cytoskeletal rearrangements and decreased endothelial cell motility, e.g., migration and tube formation. This is also reflected in an in vivo angiogenesis assay, where silencing of PHB1 blocks the formation of functional blood vessels. Collectively, our results provide evidence that PHB1 is important for mitochondrial function and prevents reactive oxygen species-induced senescence and thereby maintains the angiogenic capacity of endothelial cells.

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. Publishing Authors By Initials

M Schleicher,BR Shepherd,Y Suarez,C Fernandez-Hernando,J Yu,Y Pan,LM Acevedo,GS Shadel,WC Sessa,M Schleicher,BR Shepherd,Y Suarez,C Fernandez-Hernando,J Yu,Y Pan,LM Acevedo,GS Shadel,WC Sessa,

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Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of cell biology

VOLUME: 180

Page Numbers: 101-12

Journal Abbreviation: J. Cell Biol.

ISSN: 1540-8140

DAY: 14

MONTH: Jan

YEAR: 2008

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence.

AFFILIATION: Department of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06536, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS056206

ACRONYM: NS

MEDLINETA: J Cell Biol

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