Progressive supranuclear palsy: pathology and genetics.

Progressive supranuclear palsy: pathology and genetics. Research Abstract Details 

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Progressive supranuclear palsy: pathology and genetics. Abstract Text:

Dennis W Dickson,Rosa Rademakers,Michael L Hutton,

Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder associated with progressive axial rigidity, vertical gaze palsy, dysarthria and dysphagia. Neuropathologically, the subthalamic nucleus and brainstem, especially the midbrain tectum and the superior cerebellar peduncle, show atrophy. The substantia nigra shows loss of pigment corresponding to nigrostriatal dopaminergic degeneration. Microscopic findings include neuronal loss, gliosis and neurofibrillary tangles in basal ganglia, diencephalon and brainstem. Characteristic tau pathology is also found in glia. The major genetic risk factor for sporadic PSP is a common variant in the gene encoding microtubule-associated protein tau (MAPT) and recent studies have suggested that this may result in the altered expression of specific tau protein isoforms. Imaging studies suggest that there may be sensitive and specific means to differentiate PSP from other parkinsonian disorders, but identification of a diagnostic biomarker is still elusive.

Progressive supranuclear palsy: pathology and genetics. Publishing Authors By Initials

DW Dickson,R Rademakers,ML Hutton,

For similar microtubule-associated proteins: tau proteins research abstracts see: microtubule-associated proteins: tau proteins research

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Progressive supranuclear palsy: pathology and genetics. Journal Published:

PUBLICATION TYPE: Review

Journal: Brain pathology (Zurich, Switzerland)

VOLUME: 17

Page Numbers: 74-82

Journal Abbreviation: Brain Pathol.

ISSN: 1015-6305

DAY: 3

MONTH: Jan

YEAR: 2007

Progressive supranuclear palsy: pathology and genetics. Information

Number of References: 98

LANGUAGE: eng

NlmUniqueID: 9216781

Progressive supranuclear palsy: pathology and genetics. Keywords Mesh Terms:

KEYWORDS: tau Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Progressive supranuclear palsy: pathology and genetics. Information

Substance Name: tau Proteins

Registry Number: 0

Grant and Affiliation Information for Progressive supranuclear palsy: pathology and genetics.

AFFILIATION: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. dickson.dennis@mayo.edu

Country: Switzerland

AGENCY: United States NIEHS

GRANT: R01-ES02941

ACRONYM: ES

MEDLINETA: Brain Pathol

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