Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease.

Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Research Abstract Details 

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Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Abstract Text:

Laura Mickes,John T Wixted,Christine Fennema-Notestine,Douglas Galasko,Mark W Bondi,Leon J Thal,David P Salmon,Laura Mickes,John T Wixted,Christine Fennema-Notestine,Douglas Galasko,Mark W Bondi,Leon J Thal,David P Salmon,

Previous research suggests that patients with Alzheimer's disease exhibit cognitive impairment in the years preceding a clinical diagnosis. Memory impairments are particularly pronounced, but the relative degree to which other cognitive functions are impaired and the speed with which they decline during the preclinical years remains unclear. The authors report a detailed neuropsychological evaluation of 11 patients over the course of 3 years up to and including the 1st year of nonnormal diagnosis. The results suggest that performance falls off rapidly in all areas of cognitive functioning but that abilities thought to be subserved by the medial and lateral temporal lobes (episodic and semantic memory, respectively) appear to be substantially more impaired than those abilities thought to be subserved by the frontal lobes.

Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Publishing Authors By Initials

L Mickes,JT Wixted,C Fennema-Notestine,D Galasko,MW Bondi,LJ Thal,DP Salmon,L Mickes,JT Wixted,C Fennema-Notestine,D Galasko,MW Bondi,LJ Thal,DP Salmon,

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Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuropsychology

VOLUME: 21

Page Numbers: 696-705

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ISSN: 0894-4105

DAY: 6

MONTH: Nov

YEAR: 2007

Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 8904467

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Grant and Affiliation Information for Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease.

AFFILIATION: Department of Psychology, University of California, San Diego, CA 92093-0109, USA. lmickes@ucsd.edu

Country: United States

AGENCY: United States NIA

GRANT: R01 AG12674

ACRONYM: AG

MEDLINETA: Neuropsychology

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