Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3.

Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3. Research Abstract Details 

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Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3. Abstract Text:

Allison D Ebert,Hoo Jae Hann,Martha C Bohn,Allison D Ebert,Hoo Jae Hann,Martha C Bohn,

6-Hydroxydopamine (6-OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease (PD) in rodents. In the rat model of PD first described by Sauer and Oertel, DA neurons progressively die over several weeks following a striatal injection of 6-OHDA. It is generally assumed that DA neurons die through apoptosis after exposure to 6-OHDA, but data supporting activation of a caspase enzymatic cascade are lacking. In this study, we sought to determine if caspases involved in the intrinsic apoptotic cascade play a role in the initial stages of 6-OHDA-induced death of DA neurons in the progressively lesioned rat model of PD. We found that injection of 6-OHDA into adult rat striatum did not activate caspase-9 or caspase-3 or increase levels of caspase-dependent cleavage products in the substantia nigra at various survival times up to 7 days after the lesion, even though this paradigm produced DA neuronal loss. These data suggest that in the adult rat brain DA neurons whose terminals are challenged with 6-OHDA do not die through a classical caspase-dependent apoptotic mechanism. (c) 2007 Wiley-Liss, Inc.

Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3. Publishing Authors By Initials

AD Ebert,HJ Hann,MC Bohn,AD Ebert,HJ Hann,MC Bohn,

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Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neuroscience research

VOLUME: 86

Page Numbers: 317-25

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 1

MONTH: Feb

YEAR: 2008

Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3. Information

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LANGUAGE: eng

NlmUniqueID: 7600111

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Grant and Affiliation Information for Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3.

AFFILIATION: Department of Pediatrics, Neurobiology Program, Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Country: United States

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MEDLINETA: J Neurosci Res

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