Progressive aphasia with Lewy bodies.

Progressive aphasia with Lewy bodies. Research Abstract Details 

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Progressive aphasia with Lewy bodies. Abstract Text:

Richard J Caselli,Thomas G Beach,Lucia I Sue,Donald J Connor,Marwan N Sabbagh,

Dementia with Lewy bodies (DLB) may include both Alzheimer and Lewy body pathology, but has never been reported to cause primary progressive aphasia. We report a 69-year-old woman who died 11 years after presenting with the syndrome of progressive aphasia. Six years after aphasia onset she developed visual hallucinations, and subsequently parkinsonism. Autopsy examination revealed Alzheimer's disease (AD), cortical Lewy bodies, and depigmentation and Lewy bodies in the substantia nigra and locus ceruleus. The aphasia most likely reflected the initial onset of AD, and the psychosis and parkinsonism most likely reflected the subsequent onset of Lewy body pathology. This first reported case of progressive aphasia occurring within the context of AD and Lewy body pathology uniquely illustrates the clinical and pathological nosological relationships between these two disease processes, and demonstrates a limitation of the general term, 'DLB'.

Progressive aphasia with Lewy bodies. Publishing Authors By Initials

RJ Caselli,TG Beach,LI Sue,DJ Connor,MN Sabbagh,

For similar nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders research

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Progressive aphasia with Lewy bodies. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Dementia and geriatric cognitive disorders

VOLUME: 14

Page Numbers: 55-8

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2002

Progressive aphasia with Lewy bodies. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Progressive aphasia with Lewy bodies. Keywords Mesh Terms:

KEYWORDS: Parkinsonian Disorders

MESH TERMS: complications

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Grant and Affiliation Information for Progressive aphasia with Lewy bodies.

AFFILIATION: Department of Neurology, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, AZ 85259, USA. Caselli.Richard@Mayo.edu

Country: Switzerland

AGENCY: United States NIMH

GRANT: 1 R01 MH57899-01A1

ACRONYM: MH

MEDLINETA: Dement Geriatr Cogn Disord

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