Progressive anomia revisited: focal degeneration associated with progranulin gene mutation.

Progressive anomia revisited: focal degeneration associated with progranulin gene mutation. Research Abstract Details 

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Progressive anomia revisited: focal degeneration associated with progranulin gene mutation. Abstract Text:

In 2003 we reported a case study of a patient, Newton who presented with a progressive circumscribed anomia in association with focal left hemisphere atrophy. Remarkably, he could spell aloud the names of objects that he could not name, indicating dissociated access to phonology and orthography. We now present follow-up clinical data, post-mortem histopathological findings, and results of molecular genetic analysis. Newton showed tau-negative ubiquitin-positive histology consistent with frontotemporal lobar degeneration (FTLD) and a mutation in the progranulin (PGRN) gene. The case exemplifies the heterogeneity of clinical expression of FTLD and contributes to understanding of primary progressive aphasia.

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Progressive anomia revisited: focal degeneration associated with progranulin gene mutation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurocase : case studies in neuropsychology, neuro

VOLUME: 13

Page Numbers: 366-77

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ISSN: 1465-3656

DAY: 10

MONTH: Oct

YEAR: 2007

Progressive anomia revisited: focal degeneration associated with progranulin gene mutation. Information

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LANGUAGE: eng

NlmUniqueID: 9511374

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AFFILIATION: School of Translational Medicine, University of Manchester, Hope Hospital, Salford, UK.

Country: England

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MEDLINETA: Neurocase

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