Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution.

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Abstract Text:

Xiao-Hong Wang,Dale M Netski,Jacquie Astemborski,Shruti H Mehta,Michael S Torbenson,David L Thomas,Stuart C Ray,

Hepatic fibrosis is the primary mediator of disease due to chronic infection with hepatitis C virus (HCV). HCV exists as a quasispecies in each infected individual, and longitudinal viral sequence changes may reveal viral dynamics and the selection pressures applied by the host immune system. Thus, we hypothesized that patterns of sequence change might reveal the immunopathogenesis of fibrosis progression. We tested this hypothesis by studying individuals enrolled in a prospective study of chronic HCV-related hepatic fibrosis with little or no fibrosis at first biopsy (stage 0 or 1) and a second planned liver biopsy sample obtained 4 years later. Serum was obtained from five individuals with fast progression (FP; defined as a >2-stage change between visits) and 10 carefully matched individuals with slow progression (SP; defined as a <2-stage change between visits). We sequenced multiple cloned hemigenomic cDNAs from each person spanning six genes (core through NS3). Phylogenetic analysis revealed temporal shifts in phylogenetic clustering over time, suggesting frequent quasispecies replacement rather than simple diversification. In addition, mixed infections were detected in three subjects, with coexistence in two subjects (one FP, one SP) of subtypes 1a and 1b throughout the 4-year biopsy interval. Subjects with FP had a higher rate of evolution than subjects with SP, with a preponderance of synonymous changes, suggesting purifying selection, except in hypervariable region 1, where positive selection pressure is frequently detected. Thus, in a small but carefully matched cohort we found evidence for rapid neutral evolution of HCV in persons with rapid progression of hepatic fibrosis, suggesting higher turnover of infected cells.

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Publishing Authors By Initials

XH Wang,DM Netski,J Astemborski,SH Mehta,MS Torbenson,DL Thomas,SC Ray,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: evolution: phylogeny research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: evolution: phylogeny research

PUBMED ID PMID:

MEDLINE DATE:

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 6513-22

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 28

MONTH: 02

YEAR: 2007

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Keywords Mesh Terms:

KEYWORDS: Phylogeny

MESH TERMS: virology

Chemical & Substance for Abstract: Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution.

AFFILIATION: Viral Hepatitis Center, Div. of Inf. Dis., Department of Medicine, Johns Hopkins University School of Medicine, 1503 E. Jefferson Street, Suite 114, Baltimore, MD 21231, USA, and Southwest Hospital, Chongqing, People's Republic of China.

Country: United States

AGENCY: United States NIDA

GRANT: R01 DA16078

ACRONYM: DA

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution Related Publications

• 5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human glioblastoma U87MG cells.
• A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice.
• Adenovirus-mediated gene transfer to renal glomeruli in rodents.
• Aldosterone impairs baroreflex sensitivity in healthy adults.
• Alkaloids of Fumaria indica: Further Studies on Narceimine and Narlumidine.
• Chemical Constituents of the Leaves of Flueggea microcarpa.
• Currently evaluated calpain and caspase inhibitors for neuroprotection in experimental brain ischemia.
• Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function.
• Effect of acute hyperlipidemia on autonomic and cardiovascular control in humans.
• Effect of elevating serum lipids on luteinizing hormone response to gonadotrophin releasing hormone challenge in energy-deficient anestrous heifers.
• Effects of Exercise TVaining on Brachial and Femoral Myogenic Responses in Young Subjects: 1685: Board #175 May 30 2:00 PM - 3:30 PM.
• Estrous response of early postpartum beef heifers to progesterone and estradiol-17beta during restricted dietary energy.
• Fallen between the Cracks: Conservation Linking Land and Sea.
• Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells.
• Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.
• Increasing use of antidepressants in pregnancy.
• Induction of apoptosis and immune response by all-trans retinoic acid plus interferon-gamma in human malignant glioblastoma T98G and U87MG cells.
• Influence of static magnetic fields on pain perception and sympathetic nerve activity in humans.
• Major Alkaloid and Flavonoid of Premna integrifolia.
• Percent positive biopsy cores as a prognostic factor for prostate cancer treated with external beam radiation.
• Phenolic Constituents of Rhus semialata Leaves.
• Physalindicanols, New Biogenetic Precursors of C28-Steroidal Lactones from Physalis minima var. indica.
• Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution.
• RBx 7,796: A novel inhibitor of 5-lipoxygenase.
• Regulation and characterization of rot transcription in Staphylococcus aureus.
• Review of kinetics of chemical and photocatalytical oxidation of Arsenic(III) as influenced by pH.
• Small interfering RNA targeted to hepatitis C virus 5' nontranslated region exerts potent antiviral effect.
• Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes.
• Transfusion support to Dengue patients in a hospital based blood transfusion service in north India.
• Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor.