Programming placental nutrient transport capacity.

Programming placental nutrient transport capacity. Research Abstract Details 

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Programming placental nutrient transport capacity. Abstract Text:

A L Fowden,J W Ward,F P B Wooding,A J Forhead,M Constancia,

Many animal studies and human epidemiological findings have shown that impaired growth in utero is associated with physiological abnormalities in later life and have linked this to tissue programming during suboptimal intrauterine conditions at critical periods of development. However, few of these studies have considered the contribution of the placenta to the ensuing adult phenotype. In mammals, the major determinant of intrauterine growth is the placental nutrient supply, which, in turn, depends on the size, morphology, blood supply and transporter abundance of the placenta and on synthesis and metabolism of nutrients and hormones by the uteroplacental tissues. This review examines the regulation of placental nutrient transfer capacity and the potential programming effects of nutrition and glucocorticoid over-exposure on placental phenotype with particular emphasis on the role of the Igf2 gene in these processes.

Programming placental nutrient transport capacity. Publishing Authors By Initials

AL Fowden,JW Ward,FP Wooding,AJ Forhead,M Constancia,

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Programming placental nutrient transport capacity. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of physiology

VOLUME: 572

Page Numbers: 5-15

Journal Abbreviation: J. Physiol. (Lond.)

ISSN: 0022-3751

DAY: 26

MONTH: 01

YEAR: 2006

Programming placental nutrient transport capacity. Information

Number of References: 100

LANGUAGE: eng

NlmUniqueID: 266262

Programming placental nutrient transport capacity. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Programming placental nutrient transport capacity. Information

Substance Name: Proteins

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Grant and Affiliation Information for Programming placental nutrient transport capacity.

AFFILIATION: Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. alf1000@cam.ac.uk

Country: England

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MEDLINETA: J Physiol

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