Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Abstract Text:

Manish J Butte,Mary E Keir,Theresa B Phamduy,Arlene H Sharpe,Gordon J Freeman,

Pathways in the B7:CD28 family of costimulatory molecules regulate T cell activation and tolerance. B7-dependent responses in Cd28(-/-)Ctla4(-/-) T cells together with reports of stimulatory and inhibitory functions for Programmed Death-1 Ligand 1 or 2 molecules (PD-L1 or PD-L2) have suggested additional receptors for these B7 family members. We show that B7-1 and PD-L1 interacted with affinity intermediate to that of B7-1:CD28 and B7-1:CTLA-4. The PD-L1:B7-1 interface overlapped with the B7-1:CTLA-4 and PD-L1:PD-1 (Programmed Death-1) interfaces. T cell activation and cytokine production were inhibited by the interaction of B7-1 with PD-L1. The responses of PD-1-deficient versus PD-1,B7-1 double-deficient T cells to PD-L1 and of CD28,CTLA-4 double-deficient versus CD28,CTLA-4,PD-L1 triple-deficient T cells to B7-1 demonstrated that PD-L1 and B7-1 interact specifically to inhibit T cell activation. Our findings point to a substantial bidirectional inhibitory interaction between B7-1 and PD-L1 and add an additional dimension to immunoregulatory functions of the B7:CD28 family.

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Publishing Authors By Initials

MJ Butte,ME Keir,TB Phamduy,AH Sharpe,GJ Freeman,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

PUBMED ID PMID:

MEDLINE DATE:

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunity

VOLUME: 27

Page Numbers: 111-22

Journal Abbreviation: Immunity

ISSN: 1074-7613

DAY: 12

MONTH: 07

YEAR: 2007

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432918

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Information

Substance Name: Peptides

Registry Number: 0

Grant and Affiliation Information for Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.

AFFILIATION: Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NCRR

GRANT: S10RR017948-01A1

ACRONYM: RR

MEDLINETA: Immunity

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses Related Publications

• A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes.
• ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.
• Allergic contact dermatitis caused by the clothing dye, disperse blue 106, an important contact allergen that may be frequently missed.
• Application of biologically modeled chaotic neural network to pattern recognition in artificial olfaction.
• Arsenic upsets heartbeat. Possible early warning for cardiovascular risk.
• Biotransformation by divison-arrested and immobilized plant cells: bioconversion of monoterpenes by gamma-irradiated suspended and entrapped cells of mentha and Nicotiana.
• Biotransformation by plant cells immobilized in cross-linked polyacrylamide-hydrazide.
• Cholesterol sensitivity of endogenous and myristoylated Akt.
• Doppler optical coherence microscopy for studies of cochlear mechanics.
• Dynamic spatial processing originates in early visual pathways.
• FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor.
• Hyperreflective sign in resolved cotton wool spots using high-resolution optical coherence tomography and optical coherence tomography ophthalmoscopy.
• Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas.
• Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder.
• Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells.
• My fellow Americans...
• Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
• Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
• On-line Detection of Perceptual Signatures in Multichannel ECoG.
• Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
• Spatial frequency-specific contrast adaptation originates in the primary visual cortex.
• Study of a chaotic olfactory neural network model and its applications on pattern classification.
• Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome.
• The emerging subspecialty of Hallway Medicine.
• The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation.
• The relationship of semen quality to pregnancy rate and litter size following artificial insemination in the bitch.
• The role of cholesterol in prostate cancer.
• Variation in false-positive rates of mammography reading among 1067 radiologists: a population-based assessment.
• XFIT - an Interactive EXAFSAnalysis Program.
• p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells.