Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction.

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Abstract Text:

Many studies have shown that a one-time 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphic study during a stable period is useful for determining the prognosis of patients with chronic heart failure (CHF). However, the findings from this imaging modality are well known to be improved by medical treatment for heart failure. Accordingly, this study was performed to determine whether serial 123I-MIBG scintigraphic studies represent a reliable prognostic marker for patients with CHF. METHODS: A total of 208 patients with CHF (left ventricular ejection fraction [LVEF] < 45%) and with no cardiac events for at least 5 mo were identified on the basis of a history of decompensated acute heart failure requiring hospitalization. The delayed percentage of denervation (% denervation), delayed heart-to-mediastinum count (H/M) ratio, and washout rate (WR) were determined from the patients' 123I-MIBG images just before they left the hospital and after they had received 6 mo of treatment. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and LVEF were also determined by echocardiography at the same time points. RESULTS: Of the 208 patients, 56 experienced fatal cardiac events during the study. The mean follow-up period was 4.45 +/- 1.82 y. The baseline H/M ratio and WR; follow-up % denervation, H/M ratio, and WR; Delta-% denervation, H/M ratio, and WR; baseline LVEF; follow-up LVEDV, LVESV, and LVEF; and Delta-LVEDV, Delta-LVESV, and Delta-LVEF were significantly worse in the cardiac death group. A Cox regression analysis showed that the Delta-WR was an independent predictor of cardiac death. Moreover, sudden death occurred in 13 of the 56 patients with cardiac death. A Cox regression analysis also showed that the Delta-WR was an incremental predictor of sudden death. The cardiac death-free rate and sudden death-free rate were significantly higher in patients with Delta-WR less than -5% and Delta-WR less than -2% than in patients with Delta-WR greater than or equal to -5% and Delta-WR greater than or equal to -2%. CONCLUSION: Delta-WR obtained from serial 123I-MIBG scintigraphic studies can be useful for predicting cardiac death and sudden death in stabilized patients with CHF.

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of nuclear medicine : official publication

VOLUME: 49

Page Numbers: 907-14

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 15

MONTH: 05

YEAR: 2008

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217410

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction.

AFFILIATION: Department of Medicine and Biological Science (Cardiovascular Medicine), Gunma University Graduate School of Medicine, Gunma, Japan. s-kasama@bay.wind.ne.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Nucl Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction Related Publications

• A potential pitfall of MR imaging for assessing mandibular invasion of squamous cell carcinoma in the oral cavity.
• Additive effects of spironolactone and candesartan on cardiac sympathetic nerve activity and left ventricular remodeling in patients with congestive heart failure.
• An investigation of magnetic resonance imaging features in 14 patients with synovial chondromatosis of the temporomandibular joint.
• Changes in horizontal jaw position and intraoral pressure.
• Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction.
• Effects of aging, menopause, and hormone replacement therapy on forearm skin elasticity in women.
• Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol.
• Imaging of epithelial cancer in sub-terahertz electromagnetic wave.
• Insulin Resistance in Patients with Stroke is Related to Visceral Fat Obesity and Adipocytokines.
• Lentiviral Vector-mediated SERCA2 Gene Transfer Protects Against Heart Failure and Left Ventricular Remodeling After Myocardial Infarction in Rats.
• Long-term nicorandil therapy improves cardiac sympathetic nerve activity after reperfusion therapy in patients with first acute myocardial infarction.
• MRI and clinical findings of posterior disk displacement in the temporomandibular joint.
• MRI findings of temporomandibular joints with disk perforation.
• Mechanisms and clinical implications of asymptomatic mitral regurgitation in patients with left ventricular dysfunction.
• Network structure for control of coupled multiple nonlinear oscillators.
• Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
• Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction.
• Prostaglandin F(2alpha) Inhibits SERCA2 Gene Transcription Through an Induction of Egr-1 in Cultured Neonatal Rat Cardiac Myocytes.
• Relationship between Carotid Atherosclerosis and Lumbar Spine Bone Mineral Density in Postmenopausal Women.
• Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women.
• Relationship between metabolic syndrome and sleep-disordered breathing in patients with cardiovascular disease--metabolic syndrome as a strong factor of nocturnal desaturation.
• Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells.
• [A case of HLA-DR8 positive sarcoidosis following polymyositis and Sjögren's syndrome]
• [A case of Wegener's granulomatosis associated with the syndrome of inappropriate secretion of ADH]
• [A case of allergic bronchopulmonary aspergillosis that itraconazole showed a definite effect temporarily]
• [A case of anaphylactoid purpura associated with nephrosis followed by pulmonary tuberculosis]
• [A case of small cell lung carcinoma complicated by Lambert-Eaton myasthenic syndrome]
• [New evidence of conjugated estrogen and 17beta-estradiol]
• [Oxidative stress and mild hypertension]