Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Research Abstract Details 

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Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Abstract Text:

James R Cerhan,Sophia Wang,Matthew J Maurer,Stephen M Ansell,Susan M Geyer,Wendy Cozen,Lindsay M Morton,Scott Davis,Richard K Severson,Nathaniel Rothman,Charles F Lynch,Sholom Wacholder,Stephen J Chanock,Thomas M Habermann,Patricia Hartge,

Recent gene-expression data have suggested that host immune genetic signatures may predict outcomes in patients with follicular lymphoma. We evaluated the hypothesis that germ line common variation in candidate immune genes is associated with survival. Cox models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals for individual SNPs after accounting for age, clinical, and other demographic factors. The median age at diagnosis of the 278 patients was 57 years, and 59 (21%) of the patients died during follow-up, with a median follow-up of 59 months (range, 27-78 months) for surviving patients. SNPs in IL8 (rs4073; HR(TT)=2.14, 1.26-3.63), IL2 (rs2069762; HR(GT/TT) = 1.80, 1.06-3.05), IL12B (rs3212227; HR(AC/CC)=1.83, 1.06-3.06), and IL1RN (rs454078; HR(AA)=1.93, 1.11-3.34) were the most robust predictors of survival. A summary score of the number of deleterious genotypes from these genes was strongly associated with survival (P=.001). A risk score that combined the 4 SNPs with the clinical and demographic factors was even more strongly associated with survival (P<.001); the 5-year Kaplan-Meier survival estimates were 96% (93%-100%), 72% (62%-83%), and 58% (48%-72%) for groups at low, intermediate, and high risk, respectively. Common variation in host immune genes warrants further evaluation as a promising class of prognostic factors in follicular lymphoma.

Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Publishing Authors By Initials

JR Cerhan,S Wang,MJ Maurer,SM Ansell,SM Geyer,W Cozen,LM Morton,S Davis,RK Severson,N Rothman,CF Lynch,S Wacholder,SJ Chanock,TM Habermann,P Hartge,

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Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Blood

VOLUME: 109

Page Numbers: 5439-46

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 27

MONTH: 02

YEAR: 2007

Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Information

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LANGUAGE: eng

NlmUniqueID: 7603509

Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Keywords Mesh Terms:

KEYWORDS: Survivors

MESH TERMS: mortality

Chemical & Substance for Abstract: Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Information

Substance Name: Interleukins

Registry Number: 0

Grant and Affiliation Information for Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

AFFILIATION: Mayo Clinic College of Medicine, Rochester, MN 55905, USA. cerhan.james@mayo.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA96704

ACRONYM: CA

MEDLINETA: Blood

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