Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer.

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Abstract Text:

Hidekazu Sugasawa,Takashi Ichikura,Hironori Tsujimoto,Manabu Kinoshita,Daisaku Morita,Satoshi Ono,Kentaro Chochi,Hitoshi Tsuda,Shuhji Seki,Hidetaka Mochizuki,

BACKGROUND AND OBJECTIVES: The clinical significance of CCL5 has been reported in several malignancies. In this study, we examined the prognostic impact of serum CCL5 levels and the expression of CCL5 receptors on tumor cells in patients with gastric cancer. METHODS: Serum CCL5 levels in patients with gastric cancer were measured by enzyme-linked immunoabsorbent assay. Immunohistochemical staining of three chemokine receptors, CCR1, CCR3, and CCR5, which are known as CCL5 receptors, was performed in gastric cancer tissue. RESULTS: We found that serum CCL5 levels themselves had no impact on survival; however, higher serum CCL5 concentrations were associated with more advanced disease. Eighty-six (41%), 48 (23%), and 60 patients (28%) showed positive expression of CCR1, CCR3, and CCR5, respectively, on gastric cancer cells. Among the patients who underwent curative resection for stages II-IV disease, patients with positive CCR3 expression had significantly lower survival rates compared to those with negative CCR3 expression. Unlike CCR1, positive CCR5 expression was also associated with poorer prognosis. Multivariate analysis revealed that expression of CCR3 and/or CCR5 was an independent prognostic factor. CONCLUSIONS: Tumor expression of CCR3 and/or CCR5 (receptors for CCL5) is associated with a lower survival rate in patients with gastric cancer. J. Surg. Oncol. 2008;97:445-450. (c) 2008 Wiley-Liss, Inc.

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Publishing Authors By Initials

H Sugasawa,T Ichikura,H Tsujimoto,M Kinoshita,D Morita,S Ono,K Chochi,H Tsuda,S Seki,H Mochizuki,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of surgical oncology

VOLUME: 97

Page Numbers: 445-50

Journal Abbreviation:

ISSN: 0022-4790

DAY: 1

MONTH: Apr

YEAR: 2008

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 222643

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer.

AFFILIATION: Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Surg Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer Related Publications

• A case of atypical sporotrichosis with multifocal cutaneous ulcers.
• Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease.
• Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report.
• Cortical Aerenchyma Formation in Hypocotyl and Adventitious Roots of Luffa cylindrica Subjected to Soil Flooding.
• Degree of polarization in jointed fibers: the Lyot depolarizer.
• Development of macular hole and macular retinoschisis in eyes with myopic choroidal neovascularization.
• Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy.
• Facilitation of rotablator-stenting by measuring angiographic lesion length with the navicath (type-MUTO), a new measuring microcatheter.
• Influence of adding fish oil to parenteral nutrition on gut-associated lymphoid tissue.
• Intraluminal glutamine administration during ischemia worsens survival after gut ischemia-reperfusion.
• Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis.
• Magnesium regulates both the nucleotide binding and the enzyme activity of isolated chloroplast coupling factor 1.
• Pharmacogenetic study of methylenetetrahydrofolate reductase and thymidylate synthase in Japanese and assessment of ethnic and gender differences.
• Recovery of mRNA expression of tryptophan 2,3-dioxygenase and serine dehydratase in long-term cultures of primary rat hepatocytes.
• Renal insufficiency is related to painless myocardial infarction.
• Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells.
• Self-organizing mechanism for development of space-filling neuronal dendrites.
• Structure of regulatory networks and diversity of gene expression patterns.
• Studies on enema. I. Influences of the pH value of enema on the absorption of calcium in the large intestine.
• Studies on enema. II. Influences of various narcotics on the absorption of calcium and histamine in the large intestine.
• The insulin sensitizer pioglitazone improves the deterioration of ischemic preconditioning in type 2 diabetes mellitus rats.
• Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions.
• Xe capillary target for laser-plasma extreme ultraviolet source.
• [An elderly case of recurrent colon cancer responding to weekly s-1 chemotherapy leading to partial response.]
• [Classification criteria for severity of adverse drug reactions]
• [Experimental study on the treatment of pulmonary circulatory disturbances in cardiogenic shock]
• [Linguistic studies in medical settings. Part 1. Human relationships in medicine observed in conversation]
• [Reporting system for adverse drug reactions and infections]
• [Surgical experiences with heart injuries]
• [Surgical treatment of atresia of the left coronary artery ostium]