Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic Peptide.

Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic Peptide. Research Abstract Details 

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Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic Peptide. Abstract Text:

Bogdan A Popescu,Andreea C Popescu,Francesco Antonini-Canterin,Daniela Rubin,Piero Cappelletti,Rita Piazza,Carmen Ginghina,Doina Dimulescu,Carmen C Beladan,Gian Luigi Nicolosi,Bogdan A Popescu,Andreea C Popescu,Francesco Antonini-Canterin,Daniela Rubin,Piero Cappelletti,Rita Piazza,Carmen Ginghina,Doina Dimulescu,Carmen C Beladan,Gian Luigi Nicolosi,Bogdan A Popescu,Andreea C Popescu,Francesco Antonini-Canterin,Daniela Rubin,Piero Cappelletti,Rita Piazza,Carmen Ginghina,Doina Dimulescu,Carmen C Beladan,Gian Luigi Nicolosi,

Background: Left atrial (LA) volume and B-type natriuretic peptide (BNP) represent powerful outcome predictors in patients with heart failure (HF).Aim: To assess the comparative prognostic role of LA volume (indexed to body surface area, LAVi), left ventricular diastolic dysfunction (LVDD) and BNP levels on long-term outcome in patients with symptomatic but stable chronic HF. Methods: We studied consecutively 46 patients with symptomatic stable chronic HF (73 +/- 10 years, 30 men), in sinus rhythm, without significant valvular disease. Echocardiographic measurements included: LV mass, LV volumes and ejection fraction, and LAVi. LVDD was graded using a comprehensive Doppler algorithm. Blood taken before echocardiography was assayed for BNP levels. Primary end point was combined: all-cause mortality and hospitalization for worsening HF. Results: During 20 +/- 14 months of follow-up 19 events occurred: 8 deaths, and 11 hospitalizations for HF. In univariate analyses LAVi, LVDD, BNP levels, LV ejection fraction, LV volumes, and LV mass were significant outcome predictors (P < 0.05). At multivariate regression LAVi was the only independent predictor of outcome (hazard ratio: 1.03 per 1 ml/m(2) increase, 95% CI: 1.01-1.06, P = 0.02). Conclusion: Although directly related to LVDD and to BNP levels, only LAVi emerged as an independent outcome predictor in this cohort of elderly patients with symptomatic stable chronic HF.

Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic Peptide. Publishing Authors By Initials

BA Popescu,AC Popescu,F Antonini-Canterin,D Rubin,P Cappelletti,R Piazza,C Ginghina,D Dimulescu,CC Beladan,GL Nicolosi,BA Popescu,AC Popescu,F Antonini-Canterin,D Rubin,P Cappelletti,R Piazza,C Ginghina,D Dimulescu,CC Beladan,GL Nicolosi,BA Popescu,AC Popescu,F Antonini-Canterin,D Rubin,P Cappelletti,R Piazza,C Ginghina,D Dimulescu,CC Beladan,GL Nicolosi,

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Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic Peptide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Echocardiography (Mount Kisco, N.Y.)

VOLUME: 24

Page Numbers: 1035-43

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ISSN: 0742-2822

DAY: 16

MONTH: Nov

YEAR: 2007

Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic Peptide. Information

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LANGUAGE: eng

NlmUniqueID: 8511187

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AFFILIATION: "Prof. Dr. C. C. Iliescu" Institute of Cardiovascular Diseases, Bucharest, Romania.

Country: United States

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MEDLINETA: Echocardiography

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