Profiles of serum proteins and free amino acids associated with chloroquine retinopathy.

Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Research Abstract Details 

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Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Abstract Text:

PURPOSE: The effects of chronic chloroquine administration on serum proteins and free amino acids of rabbits and the accompanying ultrastructural changes in the retina were investigated. METHODS: Thirty pigmented rabbits were injected intramuscularly with chloroquine diphosphate (14 mg/Kg bw). Fifteen rabbits served as control. Blood samples drawn after 1, 2, 3, 4, 5, 6 and 12 months were assayed for serum proteins by Bio-analytic kits and horizontal electrophoretic technique. Free amino acids were determined by Beckman analyzer. Central retinal tissue was fixed in 4% glutaraldehyde, embedded in araldite CY212 and sectioned for ultrastructural examination. RESULTS: Histopathologic changes were apparent within three months, initially affecting the pigment epithelium and photoreceptors and later involving the remaining neuroretinal layers. Hypoproteinemia gradually developed mainly due to a sharp drop in albumin and alpha 1 and 2 globulin fractions, inspite of an increase in beta and gamma globulin fractions. The concentration of non-essential amino acids varied considerably from a depletion of taurine, aspartine, glutamine, tryptophan and arginine to an increase of serine, alanine, GABA and ornithine. The most outstanding effect was the disappearance of tyrosine and its return to normal value at the end of the experiment. CONCLUSION: The disturbances in protein pattern and free amino acid levels are an indication of chloroquine toxicity and may be implicated in the retinopathy.

Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Publishing Authors By Initials

For similar eye diseases: retinal diseases research abstracts see: eye diseases: retinal diseases research

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Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta ophthalmologica Scandinavica

VOLUME: 76

Page Numbers: 422-30

Journal Abbreviation: Acta Ophthalmol Scand

ISSN: 1395-3907

DAY: 17

MONTH: Aug

YEAR: 1998

Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Information

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LANGUAGE: eng

NlmUniqueID: 9507578

Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Keywords Mesh Terms:

KEYWORDS: Retinal Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Information

Substance Name: Chloroquine

Registry Number: 54-05-7

Grant and Affiliation Information for Profiles of serum proteins and free amino acids associated with chloroquine retinopathy.

AFFILIATION: Zoology Dept., Faculty of Science, Cairo University, Giza, Egypt.

Country: DENMARK

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MEDLINETA: Acta Ophthalmol Scand

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