Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat.

Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat. Research Abstract Details 

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Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat. Abstract Text:

A Umemura,K Yamada,H Mabe,H Nagai,

Platelet-activating factor (PAF) is a phospholipid mediator implicated in a diverse range of pathological processes. Beneficial effects of PAF antagonists have been shown in various models of central nervous system ischemia. In this study, we evaluated the production of PAF during focal cerebral ischemia and reperfusion in the rat. Ischemia was induced by occlusion of the middle cerebral artery with a thread. Quantification of PAF was performed with the radioimmunoassay technique. PAF was detected in the brain under normal conditions. Tissue PAF level in the ischemic cerebral hemisphere significantly decreased by prolonged ischemia (P<.05). Conversely, the decreased tissue PAF level during ischemia was significantly increased again by reperfusion (P<.05), but was still low compared with the control. This study indicates that the production of PAF in the brain tissue decreased by prolonged ischemia, and suggests the role of PAF in the reperfusion phase rather than during ischemia in the pathophysiology of ischemic brain injury.

Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat. Publishing Authors By Initials

A Umemura,K Yamada,H Mabe,H Nagai,

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Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of stroke and cerebrovascular diseases : t

VOLUME: 6

Page Numbers: 394-7

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ISSN: 1052-3057

DAY: 26

MONTH: 09

YEAR: 2007

Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat. Information

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LANGUAGE: eng

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Country: United States

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MEDLINETA: J Stroke Cerebrovasc Dis

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