Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides.

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Abstract Text:

M J Welch,R Laforest,J S Lewis,

The field of positron emission tomography (PET) has expanded dramatically over recent years. In spite of this expansion the large majority of clinical studies are carried out utilizing one radiopharmaceutical-2-fluoro-2-deoxyglucose. Many research groups are developing novel radiopharmaceuticals. A major emphasis is on other agents labeled with 18F. Several other positron emitting radionuclides can be prepared in high yields in small biomedical cyclotrons. Some of these have half-lives that make delivery significantly easier than the delivery of 18F compounds. These radionuclides include: 64Cu (half life 12.7 h), 76Br (half life 16.2 h), 86Y (half life 14.74 h) and 124I (half life 4.2 days). The method of production of these and other 'non-standard' PET radionuclides will be discussed and the method of labeling radiopharmaceuticals with these radionuclides described. Several of these radiopharmaceuticals have been studied in animal models as well and a limited number translated to the human situation.

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Publishing Authors By Initials

MJ Welch,R Laforest,JS Lewis,

For similar chemical actions and uses: specialty uses of chemicals: laboratory chemicals: indicators and reagents: radiopharmaceuticals research abstracts see: chemical actions and uses: specialty uses of chemicals: laboratory chemicals: indicators and reagents: radiopharmaceuticals research

PUBMED ID PMID:

MEDLINE DATE:

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Journal Published:

PUBLICATION TYPE: Review

Journal: Ernst Schering Research Foundation workshop

VOLUME:

Page Numbers: 159-81

Journal Abbreviation: Ernst Schering Res. Found. Wor

ISSN: 0947-6075

DAY: 3

MONTH: 12

YEAR: 2007

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Information

Number of References: 82

LANGUAGE: eng

NlmUniqueID: 9422786

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Keywords Mesh Terms:

KEYWORDS: Radiopharmaceuticals

MESH TERMS: chemistry

Chemical & Substance for Abstract: Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Information

Substance Name: Radiopharmaceuticals

Registry Number: 0

Grant and Affiliation Information for Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides.

AFFILIATION: Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA. WelchM@mir.wustl.edu

Country: Germany

AGENCY: United States NCI

GRANT: CA9184203

ACRONYM: CA

MEDLINETA: Ernst Schering Res Found Works

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides Related Publications

• 64Cu-azabicyclo[3.2.2]nonane thiosemicarbazone complexes: radiopharmaceuticals for PET of topoisomerase II expression in tumors.
• A state space analysis of emotion and flexibility in parent-child interactions.
• Analysis of the volatile components of cheddar cheese by direct thermal desorption-GC x GC-TOF/MS.
• Brain activation when hearing one's own and others' names.
• Candida albicans biofilms produce antifungal-tolerant persister cells.
• Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial.
• Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.
• Contemporary developments in thin-layer chromatography.
• Determinants of plasma HDL concentrations and reverse cholesterol transport.
• Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals.
• Environmental impacts of dredging on seagrasses: a review.
• Hip Abductor and Knee Extensor Muscle Strength of Children with and without Down Syndrome.
• Hospital disaster preparedness in Los Angeles County.
• Identification and characterization of a cell surface protein of Prevotella intermedia 17 with broad-spectrum binding activity for extracellular matrix proteins.
• Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals.
• L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats.
• Metal-organic complexation in the marine environment.
• Multiwire Gas Proportional Counters: Decrepit Antiques or ClassicPerformers?
• Open the door whenever opportunity knocks.
• Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides.
• Quality of manufacturer provided information on safety and efficacy claims for dietary supplements for colonic health.
• Recent advances in health professional training on substance abuse disorders.
• Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode.
• Sex-linked congenital deafness.
• Spontaneous uterine infections are associated with elevated prostaglandin F(2)alpha metabolite concentrations in postpartum dairy cows.
• The early alcoholism treatment movement in Australia, 1859-1939.
• The relationship between plasma homocysteine, red cell folate and plasma vitamin B12 in a sample of the New South Wales Central Coast population.
• Transcranial magnetic stimulation: a possible treatment for TBI.
• Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
• Uterine involution and postpartum ovarian activity in Nili-Ravi buffaloes.