[Production of interleukin-11 and interleukin-6 in cultured human gingival fibroblasts with the stimulation of lipopolysacchrides]

[Production of interleukin-11 and interleukin-6 in cultured human gingival fibroblasts with the stimulation of lipopolysacchrides] Research Abstract Details 

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[Production of interleukin-11 and interleukin-6 in cultured human gingival fibroblasts with the stimulation of lipopolysacchrides] Abstract Text:

Lu He,Toshiyuki Nagasawa,Isao Ishikawa,

OBJECTIVE: To observe the effects of Porphyromonas gingivalis (Pg), Actinobacillus actinomycetemcomitans (Aa), Escherichia coli (Ec) lipopolysacchrides (LPS) on the production of IL-11 and IL-6 from healthy human gingival fibroblasts (HGF), and the effects of endogenous prostaglandin on HGF IL-11 and IL-6 production stimulated with the above LPS. METHODS: HGF were stimulated with Pg-, Aa-, Ec-LPS of different concentrations (0.1, 1, 10 mg/L) for 24 h. And HGF were also stimulated with the combinations of 10 mg/L Pg-, Aa-, Ec-LPS and 10(-6) mol/L indomethacin respectively for 24 h. Levels of IL-11 and IL-6 in the supernatants were quantitated by ELISA. RESULTS: LPS from Aa, Ec, at the concentration of 10 mg/L and from Pg at the concentrations 1, 10 mg/L significantly augmented IL-11 production by HGF. IL-6 production was also significantly increased by stimulation with Aa-LPS at concentrations 1, 10 mg/L and with Ec-, Pg-LPS at concentrations 0.1, 1, 10 mg/L. In addition, IL-11 production was lower than IL-6 production by HGF stimulated with LPS. Indomethacin significantly inhibited IL-6 and IL-11 production in LPS-stimulated HGF. CONCLUSIONS: Aa-, Pg-, Ec-LPS may significantly increase IL-11 and IL-6 level in the supernatants of HGF, and endogenous prostaglandin may upregulate IL-11 and IL-6 production in LPS-stimulated HGF.

[Production of interleukin-11 and interleukin-6 in cultured human gingival fibroblasts with the stimulation of lipopolysacchrides] Publishing Authors By Initials

L He,T Nagasawa,I Ishikawa,

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[Production of interleukin-11 and interleukin-6 in cultured human gingival fibroblasts with the stimulation of lipopolysacchrides] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqia

VOLUME: 42

Page Numbers: 34-6

Journal Abbreviation: Zhonghua Kou Qiang Yi Xue Za Z

ISSN: 1002-0098

DAY: 2

MONTH: Jan

YEAR: 2007

[Production of interleukin-11 and interleukin-6 in cultured human gingival fibroblasts with the stimulation of lipopolysacchrides] Information

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LANGUAGE: chi

NlmUniqueID: 8711066

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AFFILIATION: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China. helubj@tom.com

Country: China

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MEDLINETA: Zhonghua Kou Qiang Yi Xue Za Z

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