Production of functional transgenic mice by DNA pronuclear microinjection.

Production of functional transgenic mice by DNA pronuclear microinjection. Research Abstract Details 

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Production of functional transgenic mice by DNA pronuclear microinjection. Abstract Text:

Anna B Auerbach,

Successful experiments involving the production of transgenic mice by pronuclear microinjection are currently limited by low efficiency of random transgene integration into the mouse genome. Furthermore, not all transgenic mice express integrated transgenes, or in other words are effective as functional transgenic mice expressing the desired product of the transgene, thus allowing accomplishment of the ultimate experimental goal - in vivo analysis of the function of the gene or gene network. The purpose of this review is to look at the current state of transgenic technology, utilizing a pronuclear microinjection method as the most accepted way of gene transfer into the mouse genome.

Production of functional transgenic mice by DNA pronuclear microinjection. Publishing Authors By Initials

AB Auerbach,

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Production of functional transgenic mice by DNA pronuclear microinjection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta biochimica Polonica

VOLUME: 51

Page Numbers: 9-31

Journal Abbreviation: Acta Biochim. Pol.

ISSN: 0001-527X

DAY: 19

MONTH: 04

YEAR: 2004

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LANGUAGE: eng

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AFFILIATION: Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, U.S.A.

Country: Poland

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MEDLINETA: Acta Biochim Pol

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