Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting.

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. Research Abstract Details 

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Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. Abstract Text:

Fujun Li,Hans Maag,Tom Alfredson,Fujun Li,Hans Maag,Tom Alfredson,

Nucleoside analogues are widely used for the treatment of antiviral infections and anticancer chemotherapy. However, many nucleoside analogues suffer from poor oral bioavailability due to their high polarity and low intestinal permeability. In order to improve oral absorption of these polar drugs, prodrugs have been employed to increase lipophilicity by chemical modification of the parent. Alternatively, prodrugs targeting transporters present in the intestine have been exploited to facilitate the transport of the nucleoside analogues. Valacyclovir and valganciclovir are two successful valine ester prodrugs transported by the PepT1 transporter. Recently, research efforts have focused on design of prodrugs for tissue specific delivery to improve efficacy and safety. This review presents advances of prodrug approaches for improved oral absorption of nucleoside analogues and recent developments in tissue targeting. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:1109-1134, 2008.

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. Publishing Authors By Initials

F Li,H Maag,T Alfredson,F Li,H Maag,T Alfredson,

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Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical sciences

VOLUME: 97

Page Numbers: 1109-34

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ISSN: 0022-3549

DAY: 5

MONTH: Mar

YEAR: 2008

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. Information

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LANGUAGE: eng

NlmUniqueID: 2985195

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AFFILIATION: Department of Pharmaceutics, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304.

Country: United States

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MEDLINETA: J Pharm Sci

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