Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway.

Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Research Abstract Details 

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Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Abstract Text:

De-Xing Hou,Dong Luo,Shunsuke Tanigawa,Fumio Hashimoto,Takuhiro Uto,Satoko Masuzaki,Makoto Fujii,Yusuke Sakata,De-Xing Hou,Dong Luo,Shunsuke Tanigawa,Fumio Hashimoto,Takuhiro Uto,Satoko Masuzaki,Makoto Fujii,Yusuke Sakata,

Much is known about the bioactive properties of green tea flavan-3-ol. However, very little work has been done to determine the properties of proanthocyanidins, another kind of polyphenols in green tea. In this study, we have investigated the anti-inflammatory effect of tea prodelphinidin B-4 3'-O-gallate (PDG) by demonstrating the inhibitory effects on cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated murine macrophage RAW264 cells. PDG caused a dose-dependent inhibition of COX-2 and iNOS at both mRNA and protein levels with the attendant decrease of prostaglandin E(2) (PGE(2)) and nitric oxide (NO) production. Molecular data revealed that PDG downregulated NF-kappaB signaling pathway. Electrophoretic mobility shift assay (EMSA) showed that PDG reduced the binding complex of NF-kappaB-DNA in the promoter of COX-2 and iNOS. Immunochemical analysis revealed that PDG suppressed LPS-induced phosphorylation and degradation of IkappaBalpha, and subsequent nuclear translocation of p65. Consequently, PDG suppressed phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta) and TGF-beta-activated kinase (TAK1). Taken together, our data indicated that PDG is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway, revealing partial molecular basis for the anti-inflammatory properties of tea PDG.

Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Publishing Authors By Initials

DX Hou,D Luo,S Tanigawa,F Hashimoto,T Uto,S Masuzaki,M Fujii,Y Sakata,DX Hou,D Luo,S Tanigawa,F Hashimoto,T Uto,S Masuzaki,M Fujii,Y Sakata,

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Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical pharmacology

VOLUME: 74

Page Numbers: 742-51

Journal Abbreviation: Biochem. Pharmacol.

ISSN: 0006-2952

DAY: 14

MONTH: 06

YEAR: 2007

Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Information

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LANGUAGE: eng

NlmUniqueID: 101032

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AFFILIATION: Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima City 890-0065, Japan.

Country: England

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MEDLINETA: Biochem Pharmacol

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