Procoagulant activity of surface-immobilized Hageman factor.

Procoagulant activity of surface-immobilized Hageman factor. Research Abstract Details 

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Procoagulant activity of surface-immobilized Hageman factor. Abstract Text:

Kaushik Chatterjee,Erwin A Vogler,Christopher A Siedlecki,

Procoagulant activity of surface-immobilized coagulation factor XIIa (activated Hageman factor) is reported. Activity of FXIIa immobilized onto the surfaces of three silanized-glass procoagulants spanning a wide range of wettability was assayed in normal and FXII-deficient plasmas. Previously published mathematical models were used to characterize the procoagulant activity of protein-immobilized materials and soluble enzymes. Results show that FXIIa activity is unrelated to underlying procoagulant surface chemistry and is similar to soluble FXIIa activity. The uninfluential role of the surface on FXIIa suggests that the solid surface activates FXII in biomaterial-induced blood coagulation but is not otherwise involved in FXIIa activity as described by the classical mechanism.

Procoagulant activity of surface-immobilized Hageman factor. Publishing Authors By Initials

K Chatterjee,EA Vogler,CA Siedlecki,

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Procoagulant activity of surface-immobilized Hageman factor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biomaterials

VOLUME: 27

Page Numbers: 5643-50

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ISSN: 0142-9612

DAY: 14

MONTH: 08

YEAR: 2006

Procoagulant activity of surface-immobilized Hageman factor. Information

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LANGUAGE: eng

NlmUniqueID: 8100316

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Grant and Affiliation Information for Procoagulant activity of surface-immobilized Hageman factor.

AFFILIATION: Department of Bioengineering, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Country: England

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MEDLINETA: Biomaterials

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