Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation.

Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Research Abstract Details 

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Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Abstract Text:

Andrea Ernst,Nils G Morgenthaler,Katharina Buerger,Richard Dodel,Carmen Noelker,Norbert Sommer,Markus Schwarz,Josef Koehrle,Andreas Bergmann,Harald Hampel,

Procalcitonin (PCT) is an established marker for severe systemic bacterial infection and sepsis in blood. Here we measured PCT by immunoassay in CSF and matched serum/plasma samples of controls and patients with different primary dementia disorders and acute neuroinflammation. PCT in CSF was significantly increased in patients with probable Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal dementia and acute neuroinflammation (encephalitis, meningitis) compared to non-demented controls. In contrast, PCT levels in matched plasma samples were normal in dementia groups, but elevated in meningitis/encephalitis. Our results indicate a central production of PCT and suggest PCT as a valuable marker candidate for the monitoring of dementia and acute neuroinflammation.

Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Publishing Authors By Initials

A Ernst,NG Morgenthaler,K Buerger,R Dodel,C Noelker,N Sommer,M Schwarz,J Koehrle,A Bergmann,H Hampel,

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Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neuroimmunology

VOLUME: 189

Page Numbers: 169-74

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 15

MONTH: 08

YEAR: 2007

Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Information

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LANGUAGE: eng

NlmUniqueID: 8109498

Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Keywords Mesh Terms:

KEYWORDS: ROC Curve

MESH TERMS: cerebrospinal fluid

Chemical & Substance for Abstract: Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation. Information

Substance Name: Calcitonin

Registry Number: 9007-12-9

Grant and Affiliation Information for Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation.

AFFILIATION: Sphingotec GmbH, Tulpenweg 6, D-16556 Borgsdorf, Germany.

Country: Netherlands

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MEDLINETA: J Neuroimmunol

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