Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy.

Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Research Abstract Details 

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Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Abstract Text:

The results of in vitro experiments showed that inhibition by procaine hydrochloride of monoamine oxidase (MAO) from either rat brain or liver was substrate-dependent. Procaine was more effective in inhibiting serotonin oxidation than phenylethylamine oxidation and had an intermediate effect on tryptamine oxidation. MAO activity in tissue homogenates from rats treated with procaine (150 mg/kg intraperitoneally) was inhibited most in liver, less in heart, and only very slightly brain for a duration of up to 8 hours. Procaine injected in that dose did not alter brain norepinephrine levels and elevated only slightly the brain serotonin levels. It did not protect against the degradation of exogenous radioactive tryptamine in brain. These data confirm and extend prior observations on in vitro inhibition of MAO by procaine and suggest that in high doses procaine may inhibit MAO weakly in vivo. If the reported usefulness of procaine preparations in treating geriatric patients indeed depends upon MAO inhibition, more effective inhibitors would seem to be available.

Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Publishing Authors By Initials

For similar organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines research abstracts see: organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines research

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Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Geriatrics Society

VOLUME: 25

Page Numbers: 90-3

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Feb

YEAR: 1977

Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Information

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LANGUAGE: eng

NlmUniqueID: 7503062

Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Keywords Mesh Terms:

KEYWORDS: Tryptamines

MESH TERMS: metabolism

Chemical & Substance for Abstract: Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy. Information

Substance Name: Monoamine Oxidase

Registry Number: EC 1.4.3.4

Grant and Affiliation Information for Procaine hydrochloride as a monoamine oxidase inhibitor: implications for Geriatric therapy.

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Country: UNITED STATES

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MEDLINETA: J Am Geriatr Soc

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