[Probe into the platelets adhesion to carbonaceous biomaterials]

[Probe into the platelets adhesion to carbonaceous biomaterials] Research Abstract Details 

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[Probe into the platelets adhesion to carbonaceous biomaterials] Abstract Text:

Bogang Li,Juanjuan Na,Guangfu Yin,Jie Yin,Changqiong Zheng,

In order to clarify the mechanism of blood coagulation for carbonaceous biomaterials, the plasma rich in platelet was obtaining through the centrifugation of fresh human blood containing anticoagulant. Adhesive tests of platelets to surfaces of DLC, diamond film(DF) and graphite was carried out at 37 degrees C. Then, morphology observation, counting and deformation index calculation of the platelets adhering to surfaces of the three kinds of materials were analyzed by SEM. It has been shown that there is no any platelet on the surface of DLC, but on DF and graphite, a lot of platelets are observed with serious deformation of type III-V. The adhesive amounts of platelet on the surface of graphite are more than those on DF, but deformation index of platelets on the surface of DF is more than that on graphite. Three major conclusions have been obtained through comparative analyses with our previous researches and related literatures: (1) Adhesion, deformation and collection of platelets occoured in succession on material surfaces resulting from protein adsorption are the major mechanism of blood coagulation of carbonaceous materials; (2) Deformation degree of platelets is more important hemocompatibility index than consumption ratio of platelets for carbonaceous materials; (3) The purer the DLC, the better is the hemocompatibility. These conclusions possess important directive function for improving and designing carbonaceous materials used in artificial mechanical heart valves.

[Probe into the platelets adhesion to carbonaceous biomaterials] Publishing Authors By Initials

B Li,J Na,G Yin,J Yin,C Zheng,

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[Probe into the platelets adhesion to carbonaceous biomaterials] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of

VOLUME: 21

Page Numbers: 12-5

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ISSN: 1001-5515

DAY: 16

MONTH: Feb

YEAR: 2004

[Probe into the platelets adhesion to carbonaceous biomaterials] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [Probe into the platelets adhesion to carbonaceous biomaterials]

AFFILIATION: College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.

Country: China

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MEDLINETA: Sheng Wu Yi Xue Gong Cheng Xue

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