Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology.

Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Research Abstract Details 

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Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Abstract Text:

Dominique Bataille,

Many peptide hormones implicated in the regulation of intermediary metabolism arise from larger precursors called prohormones. These precursors are cut into pieces by proprotein convertases, more precisely those called prohormone convertases (PCs) that cleave at the C terminus of basic doublets. The remaining basic amino acids are eliminated by a specialized carboxypeptidase, leading to the active hormone. This processing may provide, from a single precursor, several peptides with different biological activities depending on the site(s) of cleavage on the precursor. When the processing is tissue-specific, this mechanism allows to produce, from a single protein, different sets of hormones depending on the tissue considered, leading to novel regulatory processes. The archetype of such a pluripotent prohormone in the field of intermediary metabolism is pro-glucagon that, when cut by PC1 in intestinal L cells, produces four different peptides with different specificities [glicentin, oxyntomodulin (OXM), glucagon-like peptide-1, and glucagon-like peptide-2], whereas, when cut by PC2 in the alpha cells of the endocrine pancreas, glucagon is produced and, through the supplementary action of NRD convertase, a fragment of glucagon (miniglucagon) with original properties.

Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Publishing Authors By Initials

D Bataille,

For similar proteins: protein precursors research abstracts see: proteins: protein precursors research

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Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of molecular medicine (Berlin, Germany)

VOLUME: 85

Page Numbers: 673-84

Journal Abbreviation: J. Mol. Med.

ISSN: 0946-2716

DAY: 14

MONTH: 03

YEAR: 2007

Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Information

Number of References: 122

LANGUAGE: eng

NlmUniqueID: 9504370

Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Keywords Mesh Terms:

KEYWORDS: Protein Precursors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology. Information

Substance Name: Proprotein Convertases

Registry Number: EC 3.4.-

Grant and Affiliation Information for Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology.

AFFILIATION: Inserm U376, CHU Arnaud-de-Villeneuve, 34295, Montpellier Cedex 05, France. dominique.bataille@univ-montpl.fr

Country: Germany

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MEDLINETA: J Mol Med

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