Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.

Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Research Abstract Details 

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Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Abstract Text:

Jennifer L Amato,Michael G Bankson,Bryan K Yamamoto,

(+) 3,4,-Methylenedioxymethamphetamine (MDMA) is an abused drug that acutely releases serotonin (5-HT) and dopamine (DA) but produces long-term damage to 5-HT terminals. MDMA-induced DA release has been shown to be dampened by 5-HT. Although stress also activates the mesolimbic DA pathway, it is unknown if chronic stress after exposure to neurotoxic doses of MDMA will augment MDMA-induced DA release in the nucleus accumbens shell (NAcc(sh)). Rats were pretreated with MDMA (10 mg/kg x 4, intraperitoneal (i.p.)). After 7 days, rats were subjected to 10 days of chronic unpredictable stress. DA release in the NAcc(sh) and 5-HT in the ventral tegmental area (VTA) were measured after a challenge injection of MDMA (5 mg/kg, i.p.). The combination of pretreatment with MDMA+stress decreased basal concentrations of 5-HT in the VTA and DA in the NAcc(sh) and enhanced MDMA-stimulated DA release in the NAcc(sh). Pretreatment with MDMA or stress alone blunted MDMA-induced 5-HT release in the VTA. The augmentation of MDMA-induced DA release in rats pretreated with MDMA+chronic stress was attenuated by perfusion of the 5-HT(1B) antagonist, GR127935 into the VTA before the MDMA challenge injection. These results suggest that prior exposure to both MDMA and stress can produce a long-term augmentation in mesolimbic DA transmission and enhanced drug abuse vulnerability that is mediated, in part, by the 5-HT(1B) receptor in the VTA.

Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Publishing Authors By Initials

JL Amato,MG Bankson,BK Yamamoto,

For similar nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali: ventral tegmental area research abstracts see: nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali: ventral tegmental area research

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Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropsychopharmacology : official publication of

VOLUME: 32

Page Numbers: 946-54

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 2

MONTH: 08

YEAR: 2006

Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904907

Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Keywords Mesh Terms:

KEYWORDS: Ventral Tegmental Area

MESH TERMS: metabolism

Chemical & Substance for Abstract: Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.

AFFILIATION: Laboratory of Neurochemistry, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA 16866

ACRONYM: DA

MEDLINETA: Neuropsychopharmacology

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